Chemokine-directed metastasis

Contributions to Microbiology
Brigitte Gomperts, Robert M Strieter

Abstract

Over the last 20 years, the biology of chemokines has expanded beyond their initial role in mediating migration of specific subsets of leukocytes. Chemokines have been found to display pleiotropic effects for enhancing immunity to tumor-associated antigens, regulating angiogenesis, promoting proliferation/anti-apoptosis of tumor cells; and mediating tumor cell invasion and trafficking in an organ-specific manner that leads to metastases. Here, we review the importance of chemokines, especially CXC chemokines in regulating angiogenesis, tumor cell invasion and metastases; and demonstrate why they can be seen as important therapeutic targets for intervention in cancer.

Citations

May 24, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Nataša Todorović-Raković, Jelena Milovanović
Apr 6, 2007·Cancer Research·Jinming YangAnn Richmond
Feb 24, 2011·International Journal of Oncology·Crystal Johnson-HolidayJames W Lillard
Oct 13, 2009·International Journal of Cancer. Journal International Du Cancer·Otto KollmarMartin K Schilling
Jun 1, 2018·Analytical Cellular Pathology (Amsterdam)·George EmmanouilElias Kouroumalis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Related Papers

Annals of the New York Academy of Sciences
Robert M StrieterM P Keane
Cytokine & Growth Factor Reviews
Robert M StrieterM P Keane
The Journal of Clinical Investigation
Robert M StrieterM P Keane
Novartis Foundation Symposium
Robert M StrieterM P Keane
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Robert M StrieterJohn A Belperio
© 2022 Meta ULC. All rights reserved