Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice

Journal of Leukocyte Biology
Mark D WareingSally R Sarawar

Abstract

Influenza A virus replicates in the respiratory epithelium and induces an inflammatory infiltrate comprised of mononuclear cells and neutrophils. To understand the development of the cell-mediated immune response to influenza and how leukocyte trafficking to sites of inflammation is regulated, we examined the chemokine expression pattern in lung tissue from A/PR/8/34-infected C57BL/6 mice using an RNase protection assay. Monocyte chemoattractant protein 1, macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, MIP-3alpha, regulated on activation, normal T expressed and secreted (RANTES), MIP-2, and interferon-inducible protein 10 (IP-10) mRNA expression was up-regulated between days 5 and 15 after infection, consistent with a role for these chemokines in leukocyte recruitment to the lung. Low levels of expression were detected for the CC chemokine receptors (CCR)2 and CCR5, whereas CXC chemokine receptor (CXCR)3 was significantly up-regulated by day 10 after infection, coinciding with peak inflammatory cell infiltration in the airways. As RANTES, IP-10, and their receptors were up-regulated during influenza virus infection, we investigated leukocyte recruitment and viral clearance in mice deficient in RANTES or CXCR3, ...Continue Reading

References

Jul 1, 1991·The Journal of General Virology·M C EichelbergerP C Doherty
Jan 1, 1986·Current Topics in Microbiology and Immunology·G L Ada, P D Jones
Dec 1, 1994·Current Opinion in Immunology·T J Schall, K B Bacon
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Apr 29, 1998·Nature·M Baggiolini
Jun 4, 1999·Immunology Today·A Mantovani
Apr 7, 2000·The American Journal of Pathology·P HjelmströmN H Ruddle
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T JinquanL K Poulsen
Dec 9, 2000·The Journal of Biological Chemistry·P LoetscherI Clark-Lewis
Jan 4, 2001·Immunological Reviews·M Baggiolini
Feb 13, 2001·Vaccine·I JulkunenS Matikainen
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V C HuberD W Metzger
Nov 1, 2001·Respiratory Research·J B DomachowskeH F Rosenberg
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Marina SaettaLeonardo M Fabbri
Jun 29, 2002·The Journal of Infectious Diseases·Joseph B DomachowskeHelene F Rosenberg
Jul 29, 2003·European Journal of Immunology·Georgina XanthouJames Edward Pease

❮ Previous
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Citations

Jan 12, 2011·Immunology and Cell Biology·Joanna R Groom, Andrew D Luster
Jun 16, 2010·The Journal of Experimental Medicine·Jae-Kwang YooEleanor N Fish
Aug 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N LeeJ J Y Sung
Nov 19, 2013·DNA and Cell Biology·Christelle GabrielLisa F P Ng
Apr 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Daniel J J CarrJohn Ash
May 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Guang-Bi JinB Paige Lawrence
Jan 15, 2011·Clinical Microbiology Reviews·Marjolaine VareilleNicolas Regamey
Dec 17, 2008·Journal of Virology·Ramtin RahbarEleanor N Fish
Mar 26, 2010·Journal of Virology·Risa NakamuraYasunobu Yoshikai
Jul 5, 2005·Journal of Virology·Bong Joo LeeSally R Sarawar
Oct 29, 2008·Annual Review of Immunology·Jacob E Kohlmeier, David L Woodland
Feb 23, 2008·American Journal of Respiratory and Critical Care Medicine·Michael A O'ReillyB Paige Lawrence
Jun 12, 2008·Blood·Jennifer P WangEvelyn A Kurt-Jones
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Javier Rangel-MorenoTroy D Randall
May 28, 2014·Archives of Virology·Edgar SimulunduAyato Takada
Jan 1, 2015·Journal of Proteomics·Olgica TrenchevskaDobrin Nedelkov
Nov 29, 2008·European Journal of Immunology·Shaza A FadelAndrew D Luster
May 15, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J KwunS J Knechtle
Jan 5, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Amber M Smith, Alan S Perelson
Dec 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S S WeigtJ A Belperio
Nov 26, 2008·Biochemical Pharmacology·Jennifer L Head, B Paige Lawrence
Feb 28, 2016·Journal of Theoretical Biology·Drew LevinFrederick Koster
Jan 3, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Timothy J PowellRichard W Dutton
Jan 1, 2010·The American Journal of Pathology·Lian Ni LeeSally R Sarawar

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