PMID: 7545093Sep 1, 1995Paper

Chemokine expression in rheumatoid arthritis (RA): evidence of RANTES and macrophage inflammatory protein (MIP)-1 beta production by synovial T cells

Clinical and Experimental Immunology
E RobinsonE N Fish

Abstract

Earlier studies from this laboratory provided evidence for restricted cytokine expression in the T cell population in RA tissues. Specifically, IL-2, IL-4, IL-6 and interferon-gamma (IFN-gamma) gene expression levels were low. The selective chemoattractant and activation effects of chemokines on leucocytes identify them as potentially ideal candidates in mediating selective inflammatory processes in RA. Accordingly, we undertook studies to examine constitutive chemokine gene expression in RA tissues. RANTES, monocyte chemotactic protein-1 (MCP-1) and MIP-1 beta gene expression was examined in both the T and non-T cell populations in RA peripheral blood (PB), synovial fluid (SF) and synovial tissues (ST). Our results identified elevated levels of both RANTES and MIP-1 beta gene expression in circulating RA PB and SF T cells. By contrast, MCP-1 expression was virtually absent in RA PB, yet elevated MCP-1 mRNA levels were detected primarily in the non-T cell populations of the SF and ST samples. Histological examination of affected rheumatoid joints revealed extensive RANTES and MIP-1 beta expression in sites of lymphocyte infiltration and cell proliferation, namely the synovial lining and sublining layers. Fractionation or RA ST ...Continue Reading

References

Sep 1, 1992·The Journal of Clinical Investigation·A E KochR M Strieter
May 1, 1991·Cytokine·T J Schall
Jun 1, 1990·The Journal of Experimental Medicine·C O ZachariaeK Matsushima
Aug 1, 1988·Clinical Immunology and Immunopathology·P J HertzogA W Linnane
Aug 1, 1989·Cellular Immunology·D E YocumP Scuderi
Sep 1, 1989·Clinical Immunology and Immunopathology·H TabataH Nakamura
Feb 1, 1986·The Journal of Clinical Investigation·J M DayerC A Dinarello
Mar 1, 1988·The Journal of Experimental Medicine·M LotzD A Carson
Aug 1, 1988·Journal of Autoimmunity·N Talal, E Flescher
Jul 31, 1986·Biochemical and Biophysical Research Communications·J Varga, S A Jimenez
Feb 1, 1985·Arthritis and Rheumatism·G Husby, R C Williams
Jun 1, 1984·Experimental Cell Research·I SchoberH Kirchner
Jul 1, 1993·Arthritis and Rheumatism·E ChenE N Fish

❮ Previous
Next ❯

Citations

Dec 4, 1998·Springer Seminars in Immunopathology·R Thomas
Dec 7, 2000·Immunology·I J CraneJ V Forrester
Mar 20, 2002·Shock·Ulrich C LienerFlorian Gebhard
Sep 16, 2006·Rheumatology International·Junya MiyataSaburo Sone
Jul 30, 2008·The FEBS Journal·Takuji IwamotoShigeki Momohara
Aug 2, 2013·Journal of Leukocyte Biology·Lorena Álvarez-RodríguezVíctor Manuel Martínez-Taboada
Nov 29, 2014·Current Osteoporosis Reports·Lara LongobardiAnna Spagnoli
Dec 4, 1998·Springer Seminars in Immunopathology·Z SzekaneczA E Koch
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R A HellerR W Davis
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Francis G Blankenberg, H William Strauss
Jan 5, 2002·Arthritis and Rheumatism·J H RuthA E Koch
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Francis G BlankenbergH William Strauss
Nov 18, 2006·Clinical Rheumatology·Eiji TorikaiAkira Nagano
Jun 11, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Naomi OguraToshirou Kondoh
Jan 26, 2010·The Journal of Biological Chemistry·Anna Maria PiccininiAndreas J Kungl
Mar 30, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Naomi OguraToshirou Kondoh
Oct 5, 2010·Journal of Clinical Immunology·Chun XieChandra Mohan
Jan 18, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Paula B DonateFernando Q Cunha
Feb 7, 1998·The Journal of Biological Chemistry·M Wong, E N Fish
Jun 26, 2002·The Journal of Pathology·Angela M PattersonJim Middleton
Jul 30, 2008·Clinical Rheumatology·Piotr Adrian KlimiukStanislaw Sierakowski
Oct 1, 2009·Arthritis and Rheumatism·Paul D DoodesAlison Finnegan
Apr 14, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marlon P QuinonesSeema S Ahuja
Dec 25, 2009·The Journal of Rheumatology·Woon Pang KuanEdmund K Li
Aug 24, 2007·Clinical Pharmacokinetics·Alan T ClucasRonald P Gladue
May 15, 2015·Protein Engineering, Design & Selection : PEDS·Tanja GerlzaAndreas J Kungl
Dec 1, 2013·Auto- Immunity Highlights·E W BrenuS M Marshall-Gradisnik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.