Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jenny MiuN H Hunt

Abstract

Cerebral malaria (CM) can be a fatal manifestation of Plasmodium falciparum infection. Using murine models of malaria, we found much greater up-regulation of a number of chemokine mRNAs, including those for CXCR3 and its ligands, in the brain during fatal murine CM (FMCM) than in a model of non-CM. Expression of CXCL9 and CXCL10 RNA was localized predominantly to the cerebral microvessels and in adjacent glial cells, while expression of CCL5 was restricted mainly to infiltrating lymphocytes. The majority of mice deficient in CXCR3 were found to be protected from FMCM, and this protection was associated with a reduction in the number of CD8+ T cells in brain vessels as well as reduced expression of perforin and FasL mRNA. Adoptive transfer of CD8+ cells from C57BL/6 mice with FMCM abrogated this protection in CXCR3-/- mice. Moreover, there were decreased mRNA levels for the proinflammatory cytokines IFN-gamma and lymphotoxin-alpha in the brains of mice protected from FMCM. These data suggest a role for CXCR3 in the pathogenesis of FMCM through the recruitment and activation of pathogenic CD8+ T cells.

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J D SedgwickV ter Meulen
Jun 1, 1988·Parasitology·C M ThumwoodW B Cowden
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G E GrauP Vassalli
Nov 14, 1997·Infection and Immunity·V M JenningsR L Hunter
Apr 6, 1999·Journal of Neurovirology·J Hesselgesser, R Horuk
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·K E BalashovW W Hancock
Jun 11, 1999·The American Journal of Physiology·M Ho, N J White
Oct 26, 1999·Trends in Neurosciences·V C Asensio, I L Campbell
Dec 22, 1999·Journal of Neurovirology·A R Glabinski, R M Ransohoff
Jan 5, 2000·Microbes and Infection·N FavreP F Piguet
Apr 20, 2000·Redox Report : Communications in Free Radical Research·S PotterN H Hunt
Oct 4, 2000·The Journal of Experimental Medicine·L IziksonA D Luster
Nov 7, 2000·Journal of Neuroimmunology·M E DorfY Luo
Nov 21, 2000·The Journal of Experimental Medicine·W W HancockC Gerard
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M T LiuT E Lane
Oct 12, 2001·Glia·F Aloisi
Oct 12, 2001·Glia·Y Dong, E N Benveniste
Nov 14, 2001·Infection and Immunity·W L ChangH C van der Heyde
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SautyA D Luster
Jun 5, 2002·Journal of Neuroimmunology·Torben L SørensenFinn Sellebjerg
Jul 13, 2002·Brain Research. Brain Research Protocols·Helen J BallNicholas H Hunt
Oct 16, 2002·Trends in Parasitology·Sue AdamsGareth Turner
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elodie BelnoueLaurent Rénia

❮ Previous
Next ❯

Citations

Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shailendra Kapoor
Jun 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sally L EllisIain L Campbell
Dec 1, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rhea LongleyPhilippe Gros
Feb 14, 2012·Future Microbiology·Georges Emile Raymond Grau, Alister Gordon Craig
Oct 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miranda S OakleySheldon L Morris
Jan 31, 2014·Parasitology·Lisa J IoannidisDiana S Hansen
Sep 2, 2014·Frontiers in Cellular and Infection Microbiology·Nicholas H HuntGeorges E R Grau
Sep 25, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Matheus Batista Heitor CarneiroLeda Quercia Vieira
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gabriele S V CampanellaAndrew D Luster
Jan 23, 2010·American Journal of Respiratory and Critical Care Medicine·Philippe E Van den SteenGhislain Opdenakker
Sep 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Villegas-MendezKevin N Couper
Oct 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew J MitchellNicholas H Hunt
Jan 1, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa J IoannidisDiana S Hansen
Feb 17, 2017·Journal of Medical Virology·Houshang RafatpanahSeyed Abdolrahim Rezaee
May 6, 2010·PLoS Pathogens·Diana S Hansen, Louis Schofield
Jan 12, 2011·Immunology and Cell Biology·Joanna R Groom, Andrew D Luster
Jun 23, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Villegas-MendezKevin N Couper
Apr 20, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Silvia S Kang, Dorian B McGavern
Aug 5, 2017·Frontiers in Cellular and Infection Microbiology·Josefine DunstKai Matuschewski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.