Chemokine gene variants in schizophrenia

Nordic Journal of Psychiatry
Selcuk DasdemirBedia Cakmakoglu

Abstract

Background Chemokines are known to play a major role in driving inflammation and immune responses in several neuroinflammatory diseases, including multiple sclerosis, Alzheimer's disease and Parkinson's disease. Inflammation has also been implicated in the pathogenesis of schizophrenia. Aim We aimed to investigate a potential link between chemokines and schizophrenia and analyze the role of MCP-1-A2518G, SDF-1-3'A, CCR5-delta32, CCR5-A55029G, CXCR4-C138T and CCR2-V64I gene polymorphisms in the Turkish population. Methods Genotyping was conducted by PCR-RFLP based on 140 patients and 123 unrelated healthy controls to show the relation between chemokine gene variants and schizophrenia risk. Results Frequencies of CCR5-A55029G A genotypes and CCR5-A55029G AG genotypes were found higher in patients than the controls and even also CCR2-V64I WT: CCR5-A55029G A and CCR2-V64I 64I: CCR5-A55029G A haplotypes significantly associated according to Bonferroni correction. However, no significant association was found for any of the other polymorphisms with the risk of schizophrenia. Conclusions Our findings suggest that CCR5-A55029G polymorphisms and CCR2-V64I WT: CCR5-A55029G A and CCR2-V64I 64I: CCR5-A55029G A haplotypes might have associa...Continue Reading

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Citations

Aug 27, 2016·Nordic Journal of Psychiatry·Achraf JemliBesma Bel Hadj Jrad
Nov 19, 2019·Nordic Journal of Psychiatry·Rafael Ribeiro-SantosJoão Vinícius Salgado
Mar 18, 2020·Acta Neuropsychiatrica·Mario Gennaro MazzaMassimo Clerici
Dec 31, 2019·BioMed Research International·Hana SaoudBesma Bel Hadj Jrad

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