Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Alex B LentschMichael J Edwards

Abstract

Hepatic injury induced by ischemia and reperfusion is an important clinical problem after liver resection or transplantation. Neutrophils are known to mediate the organ injury, but the precise mechanisms leading to hepatic neutrophil recruitment are undefined. Two CXC chemokines, macrophage inflammatory protein-2 (MIP-2) and KC, are potently chemotactic for neutrophils in vitro and have been reported to be involved in neutrophil-dependent inflammatory tissue injury. The objective of the present study was to determine the roles of MIP-2 and KC in the induction of hepatic ischemia/reperfusion injury. C57BL/6 mice were subjected to 90 minutes of partial hepatic ischemia followed by reperfusion. Hepatic injury was associated with neutrophil sequestration, edema, and elevated serum levels of hepatic transaminases. The expression of MIP-2 messenger RNA (mRNA) was induced within 3 hours after reperfusion, before any detectable increase in neutrophil accumulation, and was also increased to a greater extent in the ischemic lobe after 9 hours of reperfusion. These data suggest that MIP-2 may be involved in the initial recruitment of neutrophils to the ischemic lobe. In contrast, KC mRNA expression was not increased after 3 hours of reper...Continue Reading

Citations

Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshidomeA B Lentsch
Nov 5, 2010·Cell and Tissue Research·Paulina M KowalewskaAlison E Fox-Robichaud
Jun 15, 2010·Biological Trace Element Research·Nozomu SakaiDale A Schuschke
Dec 29, 1998·Transplantation Proceedings·S Massberg, K Messmer
Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dean M AnselmoDouglas G Farmer
Mar 2, 2002·Immunology·Maureen N Ajuebor, Mark G Swain
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LentschM J Edwards
Nov 2, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·H R Rosen
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas A MooreTheodore J Standiford
Mar 20, 2010·Cardiovascular Research·Stephen F Rodrigues, D Neil Granger
Jan 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·David H AdamsHartmut Jaeschke
Apr 20, 2002·Transplantation·Atsushi KatoAlex B Lentsch
Oct 26, 2005·Shock·Tomohisa OkayaAlex B Lentsch
Feb 18, 2010·Transplantation·Yoichiro UchidaJerzy W Kupiec-Weglinski
Dec 20, 2007·International Clinical Psychopharmacology·Shabnam SoodMaria-Jesus Bailon
Jun 1, 2012·Journal of Gastroenterology and Hepatology·Nozomu SakaiAlex B Lentsch
Oct 7, 2009·Pharmacological Reviews·Xiaomin DengRobert A Roth
May 30, 2008·American Journal of Physiology. Cell Physiology·Elizabeth GallowayAlex B Lentsch
May 8, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Junquan XuJacquelyn J Maher
Mar 7, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satoshi KubokiCharles C Caldwell
Nov 27, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Thorsten EismannAlex B Lentsch
Sep 1, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andreas Pascher, Jochen Klupp
Jan 8, 2014·Archives of Trauma Research·Dimitrios PapadopoulosGeorgios Tsoulfas
Sep 3, 2010·Gastroenterology Research and Practice·John EvankovichAllan Tsung
Jan 3, 2014·Clinical & Developmental Immunology·Bin LiuLu-Nan Yan
Nov 15, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tomohisa Okaya, Alex B Lentsch
Jul 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tadashi HasegawaHartmut Jaeschke
Jul 9, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Charles C CaldwellAlex B Lentsch
Sep 5, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satoshi KubokiAlex B Lentsch
Dec 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satoshi KubokiAlex B Lentsch
Feb 20, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tadashi HasegawaHartmut Jaeschke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Alex B LentschMichael J Edwards
The American Journal of Pathology
Hiroyuki YoshidomeAlex B Lentsch
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Hiroyuki YoshidomeAlex B Lentsch
© 2022 Meta ULC. All rights reserved