Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors

World Journal of Gastroenterology : WJG
Jordi Camps, Jorge Joven

Abstract

The incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing. Despite this is apparently associated with the growing increase in obesity, insulin resistance and obesity-related metabolic disturbances their presence is not a necessary or sufficient condition to explain the accumulation of fat in the liver. Conversely, NAFLD is a predictor of other metabolic risks. NAFLD is currently the most frequent chronic liver disease but should not be considered benign or anecdotic because a considerable proportion of patients with NAFLD progress to cirrhosis and end-stage liver disease. Consequently, the search for alternative molecular mechanisms with therapeutic implications in NAFLD and associated disorders deserves a careful consideration. Mitochondria are possible targets as these organelles generate energy from nutrient oxidation. Some findings, generated in patients with extreme obesity and in murine models, support the notion that NAFLD could be a mitochondrial disease. This is plausible because mitochondrial dysfunction affects the accumulation of lipids in hepatocytes and promotes lipid peroxidation, the production of reactive oxygen species, the release of cytokines causing inflammation and ...Continue Reading

References

Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
May 18, 2004·Biochemical and Biophysical Research Communications·Bharti MacknessMike Mackness
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
Jan 13, 2006·Biochemical and Biophysical Research Communications·Mònica TousJorge Joven
Apr 19, 2006·Journal of Hepatology·John Willy HaukelandPål Aukrust
Jan 3, 2007·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·J A Solís HerruzoM T Muñoz Yagüe
Oct 9, 2007·Experimental and Molecular Pathology·Anna RullJorge Joven
May 1, 2008·Current Diabetes Reports·Nimantha Mark Wilfred de Alwis, Christopher Paul Day
Oct 29, 2008·Seminars in Liver Disease·Nila Rafiq, Zobair M Younossi
Mar 4, 2009·Critical Reviews in Clinical Laboratory Sciences·Jordi CampsJorge Joven
Apr 29, 2009·World Journal of Gastroenterology : WJG·Jordi CampsJorge Joven
Jul 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nathan A JohnsonJacob George
Oct 27, 2009·The Journal of Clinical Investigation·Rajat SinghMark J Czaja
Dec 17, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cecilia SöderbergRolf Hultcrantz
Jan 19, 2010·Annual Review of Pathology·Dina G TiniakosElizabeth M Brunt
Feb 23, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P LoriaUNKNOWN NAFLD Expert Committee of the Associazione Italiana per lo studio del Fegato
Mar 12, 2010·Advances in Experimental Medicine and Biology·Jordi CampsJorge Joven
Dec 2, 2011·The Journal of Nutritional Biochemistry·Kyoko Nomura, Toshikazu Yamanouchi
May 19, 2012·Cell Death and Differentiation·K Liu, M J Czaja
Aug 18, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·E Matthew MorrisJamal A Ibdah
Jan 18, 2013·Nature·Luke A J O'Neill, D Grahame Hardie
Jan 29, 2013·World Journal of Hepatology·Víctor VargasJulia Peinado-Onsurbe
Jan 30, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Scott RectorJamal A Ibdah
Feb 7, 2014·Critical Reviews in Food Science and Nutrition·Jorge JovenUNKNOWN Bioactive Food Components Platform
Mar 19, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elena Sierra-FilardiAngel L Corbí
Mar 29, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E Rodríguez-GallegoJ Joven

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Citations

May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kazuhiko KotaniAlejandro Gugliucci

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