Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Pirus GhadjarUlrich Keilholz

Abstract

The liver is the primary organ of metastasis in colorectal cancer (CRC). Chemokine receptor CCR6 is expressed on a subset of T cells and is associated with their migration into the liver. This study was performed to analyze a possible association between CCR6 expressed by primary CRC and liver metastases. CCR6 expression levels were evaluated by immunohistology in 64 CRC primary tumor specimens. Twenty-four of 64 patients had synchronous liver metastases. Evaluation of immunostaining was performed semiquantitatively by visual assessment and quantitatively by digital image analysis (DIA). Multiple logistic regression analysis was performed to assess relevant parameters for liver metastases. CCR6 expression was verified in all 64 primary tumor specimens with considerable variations in intensity; 21 tumors (33%) demonstrated weak CCR6 staining, 32 (50%) demonstrated intermediate staining, and 11 (17%) demonstrated strong staining. Quantitative assessment by DIA showed an up to 5-log difference in CCR6 values. CCR6 staining was significantly stronger in tumor cells compared with adjacent colon epithelial cells (P < .0005). Multiple logistic regression analysis, controlling for age, sex, tumor stage, nodal status, pathologic grade, ...Continue Reading

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Citations

May 10, 2008·Journal of Cancer Research and Clinical Oncology·Pirus GhadjarUlrich Keilholz
Aug 19, 2011·International Journal of Clinical Oncology·Kenji KawadaYoshiharu Sakai
Sep 11, 2007·Cancer Metastasis Reviews·Seema SinghRakesh K Singh
Nov 28, 2012·Clinical & Experimental Metastasis·A A P SlesserP Tekkis
Sep 29, 2011·Pathology Oncology Research : POR·Maria Gabriela GasparinhoPaula Chaves
Mar 22, 2012·Journal of Translational Medicine·Alberto FusiUlrich Keilholz
May 13, 2010·Journal of Translational Medicine·Claudia RubieMartin K Schilling
Sep 29, 2011·PloS One·Sophie KirshbergOri Wald
Feb 25, 2014·Journal of Translational Medicine·Claudia RubieMathias Glanemann
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Sep 10, 2014·Journal of Cellular Physiology·Chih-Chien ChinWen-Shih Huang
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Dec 17, 2009·Cytokine & Growth Factor Reviews·Alberto MantovaniRaffaella Bonecchi
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Jun 6, 2015·Cytokine·Gang HanChengjun Li
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