Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer

Cancer Science
Takuya AkashiHideki Fuse

Abstract

The chemokine receptor CXCR4 has been reported to be aberrantly expressed in human cancers and has also been shown to participate in the development of cancer metastasis. The present study was carried out to assess immunohistochemically the pattern of CXCR4 expression in patients with metastatic prostate cancer. We analyzed whether there may be an association between CXCR4 expression and prognosis. Fifty-two patients who received hormonal therapy were enrolled. Specimens were obtained from transperineal needle biopsy before treatment, and were stained with antihuman CXCR4 antibody. We also evaluated the pathological grade, extent of bony metastasis, clinical response to hormonal therapy, and patient prognosis. CXCR4 was detected in 94.2% patients. Its expression showed no association with pathological grade, extent of bony metastasis, or clinical response to hormonal therapy. Patients with a high expression of CXCR4 in tumors had poorer cancer-specific survival than those with low expression of CXCR4. CXCR4 expression is a useful prognostic factor for patients with metastatic prostate cancer treated with androgen-withdrawal therapy.

References

Mar 1, 1992·Human Pathology·D F Gleason
Jun 11, 1999·Advances in Immunology·E C ButcherM Briskin
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H GeminderA Ben-Baruch
Jun 13, 2002·The Journal of Investigative Dermatology·Aimee S Payne, Lynn A Cornelius
May 23, 2003·Journal of Cellular Biochemistry·Yan-Xi SunRussell S Taichman
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joshua B RubinRosalind A Segal
Mar 23, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-P SpanoJ-C Soria
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Merav Darash-YahanaAmnon Peled
Jun 23, 2004·Biochemical and Biophysical Research Communications·M TakenagaR Igarashi
Dec 3, 2004·Cancer Research·Matthew C P SmithGary D Luker
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefania ScalaGiuseppe Castello
Sep 24, 2005·Mini Reviews in Medicinal Chemistry·Erik De Clercq
Dec 14, 2005·Breast Cancer Research and Treatment·Ombretta SalvucciMark Basik
Mar 11, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yoshinao OdaMasazumi Tsuneyoshi

❮ Previous
Next ❯

Citations

Oct 17, 2009·Pathology Oncology Research : POR·Lukasz KruszynaPaweł P Jagodziński
Dec 21, 2011·Prostate Cancer and Prostatic Diseases·G GueronE Vazquez
Apr 22, 2010·DNA and Cell Biology·Łukasz KruszynaPaweł P Jagodziński
Jul 9, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jia WangZehua Wang
Nov 16, 2010·Molecular Cancer Research : MCR·Mahandranauth A ChetramCimona V Hinton
Aug 2, 2013·Molecular Cancer·M Katie Conley-LaCombSreenivasa R Chinni
Apr 6, 2013·Critical Reviews in Eukaryotic Gene Expression·Nicole SalazarBal L Lokeshwar
Feb 6, 2013·Theranostics·Bikash DebnathNouri Neamati
Jan 30, 2014·BMC Urology·Donald WongSreenivasa R Chinni
Sep 10, 2008·PPAR Research·Cynthia Lee Richard, Jonathan Blay
Feb 13, 2015·Molecular Medicine Reports·Andrzej RoszakPaweł P Jagodziński
Feb 10, 2012·Advanced Drug Delivery Reviews·Stewart A Low, Jindřich Kopeček
Feb 4, 2010·Biochimica Et Biophysica Acta·Ling DengQianqian Lei
Nov 26, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M PrzybylskiP P Jagodzinski
Dec 17, 2008·Seminars in Cancer Biology·Hyunsuk ShimNobutaka Fujii
Jan 1, 2014·Journal of Molecular Signaling·Janani PanneerselvamRajagopal Ramesh
Jul 10, 2009·The Prostate·Stacy PorvasnikCharles J Rosser
Apr 12, 2011·International Journal of Cancer. Journal International Du Cancer·Muthu K ShanmugamGautam Sethi
Oct 3, 2014·International Journal of Cancer. Journal International Du Cancer·Hye Won LeeKyeung Min Joo
Jun 2, 2011·Biochemical and Biophysical Research Communications·Mahandranauth A ChetramCimona V Hinton
Jun 30, 2015·Oncogene·A C StacerG D Luker
Jun 12, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Urszula M DomanskaAnnemiek M E Walenkamp
Nov 10, 2009·Seminars in Cell & Developmental Biology·Omar E FrancoSimon W Hayward
Feb 18, 2015·Frontiers in Immunology·Maria VelaLeonor Kremer
Jun 9, 2016·International Journal of Molecular Sciences·Leah PersaudMoira Sauane
Sep 18, 2016·Journal of Cancer Research and Clinical Oncology·Arezoo RastiZahra Madjd
Jan 10, 2014·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Cheng-Zhi XuRun-Jie Shi
Nov 5, 2016·Molecular Cancer·M Katie Conley-LaCombSreenivasa R Chinni
Oct 12, 2011·The Journal of International Medical Research·X YaoY Chen
May 4, 2017·The Journal of Pathology·Mingang HaoJianhua Wang
May 24, 2011·Cancers·Megan N ThobeCarrie W Rinker-Schaeffer
Jan 30, 2018·Cellular & Molecular Immunology·Keqiang ChenJi Ming Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.