Chemokine receptor expression on mucosal dendritic cells from the endocervix of healthy women

The Journal of Infectious Diseases
Manyu PrakashSteve Patterson

Abstract

Dendritic cells (DCs) may be an initial target of human immunodeficiency virus (HIV) during heterosexual transmission. An analysis of DCs in the intraepithelial layer of the endocervix of the female genital tract from healthy women showed that ~20% expressed CD1a, and 30% expressed cutaneous leukocyte antigen (CLA). Langerin, a molecule associated with Langerhans DCs, was on CD1a-positive and -negative DCs and on CLA-positive cells. CCR5 and CXCR4 were detected on CD1a-positive and -negative cervical DCs. These findings suggest that DCs in the genital tract are potential targets for macrophage-tropic and lymphotropic strains of HIV.

Citations

Jan 20, 2009·Current HIV/AIDS Reports·Florian Hladik, Thomas J Hope
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May 13, 2008·Nature Reviews. Immunology·Florian Hladik, M Juliana McElrath
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Mar 17, 2006·Nature Reviews. Microbiology·Leonid Margolis, Robin Shattock
Apr 27, 2021·Critical Reviews in Microbiology·Sriram YandrapallySharmistha Banerjee

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