Chemokine receptor inhibitors as a novel option in treatment of asthma

Current Drug Targets. Inflammation and Allergy
Ian M Adcock, Gaetano Caramori

Abstract

The migration of cells towards and into the site of an inflammatory insult is critical for maintenance of the inflammatory response and its resolution. This is particularly so in the case of asthma where recruitment of key effector cells may control disease severity, responsiveness to current therapies and the airway remodelling associated with the disease. Chemokine receptor antagonists have the hope of preventing inflammatory cell recruitment to the airway and perhaps as a consequence affect the resolution of airway remodelling. A number of selective antagonists directed at various CC and CXC receptors thought to be important in asthma are currently at various stages of clinical development. Results from these studies will determine whether chemokine receptor antagonists will prove beneficial in severe glucocorticoid-dependent and -resistant asthmatic subjects. Furthermore, it is possible that early treatment with these agents may prevent the disease from becoming established.

Citations

Mar 5, 2008·Journal of Occupational Medicine and Toxicology·Gaetano CaramoriAlberto Papi
Feb 8, 2013·Multidisciplinary Respiratory Medicine·Mohammad Afzal Khan
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Yuriy LissitsynKent T HayGlass
Feb 7, 2006·European Journal of Pharmacology·Toshiyuki Yamagata, Masakazu Ichinose
Jun 18, 2009·Current Opinion in Allergy and Clinical Immunology·Dominik HartlJack A Elias

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