PMID: 9557714Apr 29, 1998Paper

Chemokine receptor utilization by human immunodeficiency virus type 1 isolates that replicate in microglia

Journal of Virology
J T ShiehF González-Scarano

Abstract

The role of human immunodeficiency virus (HIV) strain variability remains a key unanswered question in HIV dementia, a condition affecting around 20% of infected individuals. Several groups have shown that viruses within the central nervous system (CNS) of infected patients constitute an independently evolving subset of HIV strains. A potential explanation for the replication and sequestration of viruses within the CNS is the preferential use of certain chemokine receptors present in microglia. To determine the role of specific chemokine coreceptors in infection of adult microglial cells, we obtained a small panel of HIV type 1 brain isolates, as well as other HIV strains that replicate well in cultured microglial cells. These viruses and molecular clones of their envelopes were used in infections, in cell-to-cell fusion assays, and in the construction of pseudotypes. The results demonstrate the predominant use of CCR5, at least among the major coreceptors, with minor use of CCR3 and CXCR4 by some of the isolates or their envelope clones.

References

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Citations

Aug 13, 1999·AIDS Research and Human Retroviruses·S HibbittsP R Clapham
May 8, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Ravindra B KodaliMark B Taubman
Jun 1, 2006·Brain : a Journal of Neurology·Satish K PillaiJoseph K Wong
Aug 20, 2016·Journal of Neurovirology·Pratima Rawat, Stephen A Spector
Aug 28, 2001·AIDS Research and Human Retroviruses·B Schweighardt, W J Atwood
May 31, 2002·AIDS Research and Human Retroviruses·Georgette D KanmognePaula Grammas
Nov 30, 2000·Current Infectious Disease Reports·D B Clifford
Jul 19, 2002·The Journal of General Virology·Paul R Clapham, Aine McKnight
Feb 24, 2001·Endothelium : Journal of Endothelial Cell Research·D ChiG Krishnaswamy
Jul 2, 2003·Journal of Neuropathology and Experimental Neurology·Kevin RostasyBradford A Navia
Jan 5, 2005·Nature Reviews. Immunology·Francisco González-Scarano, Julio Martín-García
Jun 21, 2015·Journal of Neurovirology·Frances ZenónLoyda M Melendez
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Terry Kenakin
Oct 19, 2004·Clinical Microbiology Reviews·R Bryan RockPhillip K Peterson
May 22, 2002·Journal of Virology·Leslie A Obert, Edward A Hoover
Apr 10, 1999·AIDS·A V AlbrightF González-Scarano
Jun 30, 2006·Glia·Cathie LeoneGabriel Gras
Feb 26, 2000·Annual Review of Genetics·H TangF Wong-Staal
May 28, 2004·Journal of Virology·Michael D BobardtPhilippe A Gallay
Sep 10, 2002·AIDS·Julio Martín-GarcíaFrancisco González-Scarano

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