Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression

Cardiovascular Research
Oana Herlea-PanaJana Barlic-Dicen

Abstract

Atherosclerosis manifests itself as arterial plaques, which lead to heart attacks or stroke. Treatments supporting plaque regression are therefore aggressively pursued. Studies conducted in models in which hypercholesterolaemia is reversible, such as the Reversa mouse model we have employed in the current studies, will be instrumental for the development of such interventions. Using this model, we have shown that advanced atherosclerosis regression occurs when lipid lowering is used in combination with bone-marrow endothelial progenitor cell (EPC) treatment. However, it remains unclear how EPCs home to regressing plaques and how they augment atherosclerosis reversal. Here we identify molecules that support functional responses of EPCs during plaque resolution. Chemokines CXCL1 and CX3CL1 were detected in the vascular wall of atheroregressing Reversa mice, and their cognate receptors CXCR2 and CX3CR1 were observed on adoptively transferred EPCs in circulation. We tested whether CXCL1-CXCR2 and CX3CL1-CX3CR1 axes regulate functional responses of EPCs during plaque reversal. We show that pharmacological inhibition of CXCR2 or CX3CR1, or genetic inactivation of these two chemokine receptors interfered with EPC-mediated advanced ath...Continue Reading

References

Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L AddisonR M Strieter
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L A RobinsonT M Coffman
Jun 18, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Esther LutgensMat J A P Daemen
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Feb 26, 2003·Circulation·Christophe CombadièreZiad Mallat
Mar 12, 2003·Circulation·Hsiao D LieuStephen G Young
May 20, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Snjezana MilatovicAnn Richmond
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P KeaneRobert M Strieter
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Mar 15, 2006·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN ASTEROID Investigators
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Feb 29, 2008·Journal of Molecular and Cellular Cardiology·Emmanouil ChavakisStefanie Dimmeler
Mar 25, 2008·Trends in Biotechnology·Jerome G RoncalliDouglas W Losordo
Jul 18, 2009·Archives of Medical Research·Qing-wei JiQiu-tang Zeng
Feb 2, 2010·Nature Reviews. Drug Discovery·Rory R Koenen, Christian Weber
Apr 20, 2010·Advances in Cancer Research·Ellen C KeeleyRobert M Strieter
May 3, 2011·Cell·Kathryn J Moore, Ira Tabas
Sep 29, 2011·Stem Cells·Takayuki AsaharaHaruchika Masuda
Mar 14, 2012·Fibrogenesis & Tissue Repair·Francisco Caiado, Sérgio Dias
Feb 26, 2013·PloS One·Arun H S KumarNoel M Caplice

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Citations

Nov 7, 2016·Journal of Neuroinflammation·Lidia Garcia-BonillaJosef Anrather
Apr 20, 2018·International Journal of Rheumatic Diseases·Maryam SanjadiSaeed Aslani
Jul 4, 2018·Frontiers in Immunology·Nicoletta Del Papa, Francesca Pignataro
Nov 9, 2018·Frontiers in Cell and Developmental Biology·Yuning Hou, Chunying Li
Nov 25, 2020·Stem Cells Translational Medicine·Adil RasheedCarolyn L Cummins

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