Abstract
Chemokines and their receptors participate in pathomechanism of bronchial asthma. The aim of the study was to analyze the pattern of chemokine receptor expression on T cells in severe asthmatics and to compare to mild-to-moderate patients and controls. Flow cytometric analysis of CXCR1, CXCR2, CXCR3, CCR3, CCR4, CCR5, CCR7, CCR8 expression on CD3(+)CD8(-) and CD3(+)CD8(+) cells was performed in patients with different severity of chronic asthma and in controls. Percentages of CD3(+)CD8(+) cells expressing CXCR1 were significantly lower in severe asthmatic than in mild-to-moderate asthmatics and in controls. Percentages of CD3(+)CD8(+) cells expressing CCR7 were significantly lower in the severe asthma group than in control group. Percentages of CD3(+)CD8(-) cells expressing CXCR1, CXCR2 and CCR8 were significantly lower in the severe asthma group than in mild-to-moderate asthmatics and in controls. The number of cells CD3(+)CD8(-) and CD3(+)CD8(+) expressing of CXCR1 was significantly lower in the group of patients using more than 800μg of budesonide daily than in the group of patients using less than 400μg of budesonide. Percentages of CD3(+)CD8(-) cells expressing CXCR3, CCR4 and CCR5 were visibly higher (not significantly) i...Continue Reading
References
Feb 10, 2000·Springer Seminars in Immunopathology·U SyrbeA Hamann
Jun 8, 2001·The Journal of Clinical Investigation·P Panina-BordignonF Sinigaglia
Aug 25, 2001·American Journal of Respiratory and Critical Care Medicine·S O'SullivanL W Poulter
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·K KurashimaS Nakao
May 25, 2004·Journal of Leukocyte Biology·Suzanne L TravesLouise E Donnelly
Jul 22, 2004·Experimental Dermatology·Undine LippertChristine Neumann
Jan 15, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T KallinichR A Kroczek
Feb 3, 2005·Current Allergy and Asthma Reports·Gilles GarciaMarc Humbert
Aug 24, 2005·Nature Immunology·Shannon K BromleyAndrew D Luster
Jun 22, 2006·Current Drug Targets·Paola PaninaDaniele D'Ambrosio
Aug 22, 2006·Current Topics in Medicinal Chemistry·Jakob Busch-Petersen
Jan 20, 2007·Thorax·Yusheng QiuPeter K Jeffery
Sep 6, 2008·Clinical and Experimental Immunology·S Pucci, C Incorvaia
Sep 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R SaundersC Brightling
Feb 11, 2010·Respiratory Research·Lennart GreiffMorgan Andersson
Mar 24, 2010·Pulmonary Pharmacology & Therapeutics·Karin StrandbergKjell Larsson
Dec 17, 2011·Blood·Hiroshi TakataMasafumi Takiguchi
Apr 25, 2014·American Journal of Physiology. Endocrinology and Metabolism·Luciana BesedovskyTanja Lange
Citations
Mar 7, 2018·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Matthew WiestSangKon Oh
Dec 27, 2015·Allergy·Ulrich M ZisslerCarsten B Schmidt-Weber
Dec 12, 2019·International Journal of Laboratory Hematology·Satoru WatanabeHirokazu Murakami