Chemokine signaling controls endodermal migration during zebrafish gastrulation.

Science
Sreelaja Nair, T F Schilling

Abstract

Directed cell movements during gastrulation establish the germ layers of the vertebrate embryo and coordinate their contributions to different tissues and organs. Anterior migration of the mesoderm and endoderm has largely been interpreted to result from epiboly and convergent-extension movements that drive body elongation. We show that the chemokine Cxcl12b and its receptor Cxcr4a restrict anterior migration of the endoderm during zebrafish gastrulation, thereby coordinating its movements with those of the mesoderm. Depletion of either gene product causes disruption of integrin-dependent cell adhesion, resulting in separation of the endoderm from the mesoderm; the endoderm then migrates farther anteriorly than it normally would, resulting in bilateral duplication of endodermal organs. This process may have relevance to human gastrointestinal bifurcations and other organ defects.

References

Aug 1, 1992·Mechanisms of Development·J E HowardJ C Smith
Mar 1, 1994·Current Biology : CB·F M Watt, K J Hodivala
Aug 1, 1996·Developmental Biology·R Winklbauer, R E Keller
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Sep 10, 1999·Developmental Biology·K E McGrathJ Palis
Nov 5, 1999·Developmental Biology·J AlexanderD Y Stainier
Sep 26, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D J Roberts
Dec 4, 2001·Mechanisms of Development·S W ChongV Korzh
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nicolas B DavidAlain Ghysen
Mar 21, 2003·Developmental Biology·Holly A FieldDidier Y R Stainier
Apr 16, 2003·Differentiation; Research in Biological Diversity·Ray KellerDavid R Shook
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Alexander F Schier
Mar 20, 2004·Developmental Cell·L A Trinh, Didier Y R Stainier
Jun 16, 2004·Current Opinion in Cell Biology·Erez Raz
Feb 11, 2005·Development·Juan-Antonio MonteroCarl-Philipp Heisenberg
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qin LiJohn Y Kuwada
Mar 31, 2005·Current Biology : CB·Lilianna Solnica-Krezel
Apr 20, 2005·Current Opinion in Structural Biology·Pascal F EgeaPeter Walter
Jul 28, 2005·Anatomy and Embryology·Faisal YusufBeate Brand-Saberi
Sep 1, 2005·Neuron·Holger KnautAlexander F Schier
Nov 10, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kari DickinsonJulie C Baker
Jun 22, 2006·BMC Cell Biology·A Paul MouldMartin J Humphries
Jun 27, 2006·Nature·Elke A OberDidier Y R Stainier
Jan 24, 2007·Biochemical and Biophysical Research Communications·Akimasa FukuiMakoto Asashima
Mar 6, 2007·Developmental Cell·Xin-Xin I ZengLilianna Solnica-Krezel
Mar 6, 2007·Developmental Cell·Ian C ScottDidier Y R Stainier
Aug 21, 2007·Experimental Cell Research·Jon JonesRoman A Blaheta
Feb 23, 2008·Current Biology : CB·Guillaume PézeronNicolas B David

❮ Previous
Next ❯

Citations

Jul 26, 2013·Nature Communications·Benjamin SchmidJan Huisken
Jan 25, 2011·Nature Genetics·Alison A StatonAntonio J Giraldez
Aug 1, 2013·Human Molecular Genetics·Victor VelecelaOfelia M Martínez-Estrada
Apr 3, 2009·Current Opinion in HIV and AIDS·Ghalib Alkhatib
Oct 3, 2009·Genes & Development·Arndt F SiekmannNathan D Lawson
Nov 23, 2011·Development, Growth & Differentiation·Toshiyasu Goto, Makoto Asashima
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Aaron M Zorn, James M Wells
Dec 17, 2009·BMC Developmental Biology·Anne-Christine HickChristophe E Pierreux
Oct 12, 2012·PLoS Biology·Shu-Yu WuLilianna Solnica-Krezel
Jun 3, 2009·The International Journal of Developmental Biology·Byung-Yong ParkJean-Pierre Saint-Jeannet
Feb 6, 2013·Theranostics·Keiichi Katsumoto, Shoen Kume
Jan 11, 2014·Science·Andrea PauliAlexander F Schier
Jul 19, 2012·Annual Review of Cell and Developmental Biology·Lila Solnica-Krezel, Diane S Sepich
Jan 24, 2012·Stem Cell Research·Lloyd A PereiraAndrew G Elefanty
Sep 5, 2012·The Journal of Cell Biology·Stephanie WooDidier Y R Stainier
Oct 21, 2009·Matrix Biology : Journal of the International Society for Matrix Biology·Andrew Latimer, Jason R Jessen
Sep 11, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Wenrui Liu, Ann C Foley
Nov 14, 2012·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hisayuki NomiyamaOsamu Yoshie
Jan 31, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chih-Wei ChouYi-Wen Liu
Dec 15, 2010·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Valerie Christine Virta, Mark Scott Cooper
Aug 23, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cynthia L HsuMerrill B Hille
Sep 22, 2009·Stem Cell Research·Dennis Van HoofMichael S German
Mar 15, 2012·Seminars in Cell & Developmental Biology·Stephen W Lewellis, Holger Knaut
Aug 7, 2013·Developmental Biology·Jangwoo LeeManjong Han
May 29, 2015·Developmental Cell·Michael R M HarrisonChing-Ling Lien
Jan 28, 2015·General and Comparative Endocrinology·Jun ZouChris J Secombes
Apr 20, 2010·Trends in Cell Biology·Roberto Mayor, Carlos Carmona-Fontaine
Jul 7, 2009·Developmental Biology·Eugenia C Olesnicky KillianKristin Bruk Artinger
Mar 23, 2011·Developmental Biology·Sólveig ThorsteinsdóttirFernanda Bajanca
Nov 17, 2009·Developmental Biology·Andy Aman, Tatjana Piotrowski
Dec 17, 2014·Nature Communications·Cong XuArndt F Siekmann
Jun 2, 2016·BMC Developmental Biology·Soichiro OgakiShoen Kume
Jun 29, 2018·ELife·Michelle M CollinsDidier Yr Stainier
Apr 6, 2017·Biology Open·Lee B MilesHeather Verkade

❮ Previous
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