Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis.

World Journal of Gastroenterology : WJG
Pierre NahonNathalie Charnaux

Abstract

To explore the influence of polymorphisms in genes encoding for the chemokines Stromal cell-Derived Factor-1 (SDF-1)/CXCL12 and Monocyte Chemotactic Protein-1 (MCP-1)/CCL2, or for the chemokine receptor CCR5 on the risks of liver-related death and hepatocellular carcinoma (HCC) occurrence in hepatitis C virus (HCV)-infected patients. SDF-1 3'A, MCP-1 (-2518) and CCR5-Delta32 polymorphisms, SDF-1 alpha, Regulated upon Activation Normal T cells Expressed and Secreted (RANTES)/CCL5 and MCP-1 serum levels were determined in 120 HCV-infected patients, included at time of cirrhosis diagnosis and prospectively followed-up. During follow-up, 23/120 (19.1%) patients died and 47/120 (39.1%) developed HCC. Carriers and noncarriers of each genetic marker had similar baseline characteristics estimating the severity of liver disease. The occurrence of death or HCC during follow-up was similar among carriers and noncarriers of each polymorphism. There was no association between the carriage of mutated alleles and chemokine serum levels and the latter were not associated with the risks of death or HCC. This study suggests the lack of association of SDF-1 3'A, MCP-1 (-2518), CCR5-Delta32 polymorphisms with death and HCC occurrence in cirrhotic ...Continue Reading

References

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F MarraP Gentilini
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·N HizawaY Kawakami
Apr 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·F KusanoC Sato
Feb 24, 2001·Bratislavské lekárske listy·M Buc, M Bucova
Mar 1, 2002·Oncology·Kazuhiko KoikeMoriya Kyoji
Mar 20, 2002·Cytokine & Growth Factor Reviews·Alain P Vicari, Christophe Caux
Aug 6, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Fabio Marra
Jul 23, 2003·Journal of Hepatology·Golo AhlenstielUlrich Spengler
Nov 5, 2003·The Journal of Experimental Medicine·Santos MañesCarlos Martínez-A
Dec 3, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simon HellierAdrian V S Hill
Oct 28, 2004·Gastroenterology·E Jenny Heathcote
Mar 15, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pierre NahonMichel Beaugrand
May 25, 2006·Journal of Clinical Gastroenterology·Anna Maria TommasiAnnarosa Floreani
Mar 6, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pierre NahonMichel Beaugrand

❮ Previous
Next ❯

Citations

Dec 20, 2012·Inflammation·Khodayar GhorbanDerek Kennedy
Jun 22, 2010·Molecular Biology Reports·Lukasz KruszynaPaweł P Jagodziński
Jan 1, 2009·Immunotherapy·Trina J Stewart, Mark J Smyth
Apr 17, 2010·World Journal of Gastroenterology : WJG·Fan Huang, Xiao-Ping Geng
Apr 26, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hongxia MaHongbing Shen
Aug 27, 2010·Journal of Surgical Oncology·Chao-Bin YehShun-Fa Yang
Apr 17, 2013·Journal of Medical Virology·Hossein KhorramdelazadMohammad Kazemi Arababadi
Jul 31, 2009·International Journal of Cancer. Journal International Du Cancer·Maylis DagouassatNathalie Charnaux
May 7, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Khadija RebbaniSoumaya Benjelloun
May 23, 2012·Journal of Hepatology·Pierre Nahon, Jessica Zucman-Rossi
Sep 23, 2014·Molecular Genetics and Genomics : MGG·Yan WangZhi-Chun Feng
Dec 31, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Hossein KhorramdelazadGholamhossein Hassanshahi
Sep 6, 2014·PloS One·Isabelle MorardUNKNOWN Swiss Hepatitis C Cohort Study Group
Jun 5, 2012·Journal of Hepatology·Emilie EstrabaudTarik Asselah
Mar 17, 2016·Memórias do Instituto Oswaldo Cruz·Erinaldo Ubirajara Damasceno dos SantosPaulo Roberto Eleutério de Souza
Jun 19, 2012·Molecular Biology Reports·Ting LiuDong-Qing Ye
Dec 12, 2017·BioMed Research International·Alicja E GrzegorzewskaPaweł P Jagodziński
Aug 25, 2015·World Journal of Hepatology·Meenakshi SachdevaSunil K Arora
Oct 31, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Vasudha SambyalNeeti Rajan Singh
Jun 9, 2015·World Journal of Hepatology·Chun-Min LiangCui-Ping Zhong
Mar 1, 2019·Transplantation·Sulemon ChaudhryAdam Griesemer
Dec 22, 2012·Molecular Medicine Reports·Emmanouil LiarmakopoulosMaria Gazouli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.