Chemokines and gelatinases in the aqueous humor of patients with active uveitis

American Journal of Ophthalmology
Ahmed M Abu El-AsrarKarel Geboes

Abstract

To investigate the involvement of the chemokines CXCL10/IP-10, CXCL11/I-TAC, CXCL8/1L-8, CXCL6/GCP-2, CCL3/MIP-1alpha, and CCL18/PARC, and gelatinases A and B in uveitis. Prospective, experimental, case-control study. Aqueous humor samples from 30 patients with active uveitis, and 14 control patients and paired serum samples were assayed for chemokines with specific enzyme-linked immunosorbent assays (ELISAs) and for gelatinase levels by quantitative zymography. In control AH, none of the chemokines was detected. Gelatinase A was detected in all samples, and gelatinase B was detected in only one sample. In patients with uveitis, IP-10 was detected in all AH samples, whereas I-TAC, IL-8, GCP-2, MIP-1alpha, and PARC were detected in three, 16, six, two, and 12 samples, respectively. IP-10 levels were significantly higher in AH samples than those of serum (P =.006). Gelatinase A was detected in 29 AH samples and gelatinase B was detected in 26 samples. Gelatinase A levels were significantly higher in AH samples from patients than those of controls (P <.0001). In 11 AH samples, gelatinase B was detected in complex with lipocalin (NGAL). Disease activity correlated significantly with the levels of IP-10 (r =.627; P <.0001), gelatina...Continue Reading

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Citations

Oct 13, 2006·International Ophthalmology·Ahmed M Abu El-AsrarAbdulrahman Al-Arfaj
Apr 17, 2007·International Ophthalmology·Abdullah S Al-KharashiAhmed M Abu El-Asrar
May 5, 2007·Eye·A M Abu El-AsrarD Kangave
Apr 14, 2007·International Ophthalmology·Ahmed M Abu El-AsrarJo Van Damme
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Jan 13, 2017·Ocular Immunology and Inflammation·Matilde Ruiz-CruzGustavo Reyes-Terán
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Apr 17, 2021·Clinical Ophthalmology·Moustafa S MagliyahHassan Al-Dhibi

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