Abstract
To investigate the involvement of the chemokines CXCL10/IP-10, CXCL11/I-TAC, CXCL8/1L-8, CXCL6/GCP-2, CCL3/MIP-1alpha, and CCL18/PARC, and gelatinases A and B in uveitis. Prospective, experimental, case-control study. Aqueous humor samples from 30 patients with active uveitis, and 14 control patients and paired serum samples were assayed for chemokines with specific enzyme-linked immunosorbent assays (ELISAs) and for gelatinase levels by quantitative zymography. In control AH, none of the chemokines was detected. Gelatinase A was detected in all samples, and gelatinase B was detected in only one sample. In patients with uveitis, IP-10 was detected in all AH samples, whereas I-TAC, IL-8, GCP-2, MIP-1alpha, and PARC were detected in three, 16, six, two, and 12 samples, respectively. IP-10 levels were significantly higher in AH samples than those of serum (P =.006). Gelatinase A was detected in 29 AH samples and gelatinase B was detected in 26 samples. Gelatinase A levels were significantly higher in AH samples from patients than those of controls (P <.0001). In 11 AH samples, gelatinase B was detected in complex with lipocalin (NGAL). Disease activity correlated significantly with the levels of IP-10 (r =.627; P <.0001), gelatina...Continue Reading
References
Apr 3, 1992·Brain Research·G A RosenbergW G Stetler-Stevenson
Jul 1, 1992·Cytokine·G Opdenakker, J Van Damme
Jun 1, 1991·European Journal of Biochemistry·S MasureG Opdenakker
Jul 1, 1991·The Biochemical Journal·G MurphyA J Docherty
Jan 1, 1989·Annual Review of Immunology·T R Mosmann, R L Coffman
Mar 1, 1994·Immunology Today·G Opdenakker, J Van Damme
Jun 12, 1997·Nature·G J AdemaC G Figdor
Jan 1, 1997·International Reviews of Immunology·N Yamashita
Jan 31, 1998·The Journal of Experimental Medicine·R BonecchiF Sinigaglia
Jan 14, 1998·Current Eye Research·M J VermaD Wakefield
Apr 29, 1998·European Journal of Immunology·L PialiB Moser
Mar 14, 2000·Immunity·A Zlotnik, O Yoshie
Aug 5, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A D'HaeseG Opdenakker
Feb 24, 2001·Clinical and Experimental Immunology·K NishiojiK Kashima
Sep 28, 2001·Trends in Immunology·G OpdenakkerJ Van Damme
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T L SørensenR M Ransohoff
Feb 28, 2002·The British Journal of Ophthalmology·C CuelloN Di Girolamo
Mar 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Philippe E Van den SteenGhislain Opdenakker
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gizi WildbaumNathan Karin
Aug 23, 2002·International Ophthalmology Clinics·Yumi Imai, Shigeaki Ohno
Oct 9, 2002·The American Journal of Pathology·Masanori HangaiPeter C Brooks
Oct 18, 2002·Arthritis and Rheumatism·Noriyoshi OgawaSusumu Sugai
Oct 29, 2002·Cytokine & Growth Factor Reviews·Patricia MentenJo Van Damme
Nov 14, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Francis J DescampsGhislain Opdenakker
Jan 15, 2003·Current Eye Research·Kouichi OhtaJ Wayne Streilein
Jan 21, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anja WuytsJo Van Damme
Feb 28, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hiroshi KeinoMasahiko Usui
Mar 21, 2003·European Journal of Immunology·Isabel J CraneJohn V Forrester
Apr 30, 2003·Arthritis Research & Therapy·Ryosuke HanaokaMitsuru Adachi
Jul 17, 2003·Clinical Endocrinology·E Helen KempAnthony P Weetman
Citations
Oct 13, 2006·International Ophthalmology·Ahmed M Abu El-AsrarAbdulrahman Al-Arfaj
Apr 17, 2007·International Ophthalmology·Abdullah S Al-KharashiAhmed M Abu El-Asrar
Aug 2, 2008·Cancer Gene Therapy·M EnderlinC Dinsart
Apr 8, 2006·Eye·A M Abu El-AsrarP Kestelyn
May 5, 2007·Eye·A M Abu El-AsrarD Kangave
Feb 9, 2006·The British Journal of Ophthalmology·H TakaseM Mochizuki
Apr 14, 2007·International Ophthalmology·Ahmed M Abu El-AsrarJo Van Damme
Oct 9, 2012·Journal français d'ophtalmologie·K Lahmar-BelguendouzC Touil-Boukoffa
May 3, 2011·Immunobiology·Ahmed M Abu El-AsrarSofie Struyf
Feb 22, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ahmed M Abu El-AsrarJo Van Damme
Apr 7, 2010·Human Immunology·Yun Jong LeeYeong Wook Song
Mar 26, 2015·Experimental Eye Research·Xiangjia ZhuYi Lu
Feb 13, 2008·Journal of Cellular and Molecular Medicine·F J DescampsG Opdenakker
Jun 22, 2010·Journal of Cellular Biochemistry·José Prisco Palma-NicolásAna María López-Colomé
Aug 29, 2006·American Journal of Ophthalmology·Jae Kyoun AhnYeoung Geol Park
Oct 29, 2015·Case Reports in Ophthalmological Medicine·Juan B YepezJ Fernando Arevalo
May 26, 2015·Journal of Ophthalmic & Vision Research·María Luisa Hernández GarfellaEnrique Cervera Taulet
Aug 3, 2011·Progress in Retinal and Eye Research·Marc D de SmetSue Lightman
Nov 12, 2013·Virology·Muriel LavieChristiane Dinsart
Jan 16, 2016·PloS One·Saori OhiraHidenobu Tanihara
Jan 13, 2017·Ocular Immunology and Inflammation·Matilde Ruiz-CruzGustavo Reyes-Terán
Aug 24, 2011·Korean Journal of Ophthalmology : KJO·Ji Won Lim, Joo Hyun Park
May 10, 2007·Acta Ophthalmologica Scandinavica·Roberto Martins GonçalvesAntônio Lúcio Teixeira
May 9, 2019·International Ophthalmology·Mert SimsekPelin Yilmazbas
Aug 15, 2008·Acta Ophthalmologica·Hiroshi KeinoHiroshi Goto
Oct 18, 2018·Journal of Ophthalmic Inflammation and Infection·Sheila T Angeles-HanGary N Holland
Feb 23, 2020·Pathogens·Susu M ZughaierWilliam M Shafer
Dec 1, 2007·European Journal of Ophthalmology·M P ParoliM Paroli
May 28, 2019·World Journal of Clinical Cases·Ken SatoHiroaki Okamoto
Nov 21, 2019·Immunology Letters·Ashraf Mousavi
Mar 1, 2021·BMC Ophthalmology·Hui Wang, Yong Tao
Apr 17, 2021·Clinical Ophthalmology·Moustafa S MagliyahHassan Al-Dhibi