Chemokines and Their Receptors: Potential Therapeutic Targets for Bone Cancer Pain

Current Pharmaceutical Design
Ya-Qun ZhouDa-Wei Ye

Abstract

Bone cancer pain (BCP) is still an intractable problem currently because the analgesic pharmacological intervention remains insufficient. Thus, the development of novel therapeutic target is critical for the treatment of BCP. Emerging evidence demonstrated that some chemokines and their receptors contribute to the induction and maintenance of BCP. In this article, we reviewed the current evidence for the role of different chemokines and their receptors (e.g. CXCL12/CXCR4, CXCL1/CXCR2, CCL2/CCR2, CCL5/CCR5, CX3CL1/CX3CR1 and CXCL10/CXCR3) in mediating BCP. By extensively understanding the involvement of chemokines and their receptors in BCP, novel therapeutic targets may be revealed for the treatment of BCP.

Citations

Oct 19, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yue SunShi-Ying Yu
Nov 29, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shi-Feng WangJian-Jun Yin
Sep 1, 2017·The Journal of Pharmacology and Experimental Therapeutics·Ya-Qun ZhouDa-Wei Ye
Aug 22, 2020·Journal of Pain Research·Ashwag Yagoub AloyounyIshrat Rahman
Nov 10, 2017·Current Neuropharmacology·Ya-Qun ZhouYu-Ke Tian
May 10, 2016·Acta Pharmacologica Sinica·Zhen-Peng SongYu-Ke Tian
Jun 9, 2016·Journal of Neuroinflammation·Ya-Qun ZhouYu-Ke Tian
Jul 19, 2016·Expert Opinion on Therapeutic Targets·Ya-Qun ZhouYu-Ke Tian
Oct 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia SunDa-Wei Ye
May 26, 2020·Pharmacology & Therapeutics·Bao-Chun JiangYong-Jing Gao
Apr 27, 2019·Life Sciences·Muzammal HussainJinsong Liu
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Xihan LiYing Huang
Jun 23, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meirong LiFanghong Li

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