Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy

Journal of Leukocyte Biology
Pravin MishraAdit Ben-Baruch

Abstract

Cells of the tumor microenvironment play active roles in determining the malignancy phenotype. The host cells and the cancer cells cross-talk via a large variety of soluble factors, whose effects on both partners determine the final outcome of the tumorigenic process. In this review, we focus on the interactions between cancer cells and fibroblasts that are found in their proximity in the growing and progressing tumor and describe the roles of chemokines in mediating such cross-talks. Cancer-associated fibroblasts (CAFs, also termed tumor-associated fibroblasts) were found recently to acquire properties that promote tumor development and metastasis formation, as is also the case for specific members of the chemokine family. In this review, we suggest that there is a bidirectional cross-talk between tumor cells and CAFs, which leads via chemokine activities to increased malignancy. This cross-talk is manifested by the fact that cancer cells release factors that enhance the ability of the fibroblasts to secrete a variety of tumor-promoting chemokines, which then act back on the malignant cells to promote their proliferative, migratory, and invasive properties. The CAF-released chemokines also affect the tumor microenvironment, le...Continue Reading

References

Jun 3, 2000·Annual Review of Immunology·F SallustoA Lanzavecchia
Jul 25, 2000·Molecular Medicine Today·C C ParkM H Barcellos-Hoff
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jun 13, 2002·The Journal of Investigative Dermatology·Aimee S Payne, Lynn A Cornelius
Nov 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kevin BaconUNKNOWN IUIS/WHO Subcommittee on Chemokine Nomenclature
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Dec 21, 2002·Differentiation; Research in Biological Diversity·Isaiah J Fidler
May 6, 2003·European Journal of Immunology·Tobias SilzleLeoni A Kunz-Schughart
Aug 29, 2003·Biochemical and Biophysical Research Communications·Genichiro IshiiAtsushi Ochiai
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·Tobias SilzleLeoni A Kunz-Schughart
Mar 23, 2004·Annual Review of Immunology·Antal Rot, Ulrich H von Andrian
Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Jul 13, 2004·Seminars in Cancer Biology·Ilaria Conti, Barrett J Rollins
Nov 3, 2004·Journal of Dermatological Science·Takashi MurakamiSam T Hwang
Dec 3, 2004·Cancer Research·Natalie C DirekzeNicholas A Wright
Jun 14, 2005·Cancer Cell·Laurie E LittlepageZena Werb
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Apr 22, 2006·Contributions to Microbiology·Albert Zlotnik
May 4, 2006·International Journal of Cancer. Journal International Du Cancer·Albert Zlotnik
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·M EgebladZ Werb
Aug 2, 2006·Cell Cycle·Akira Orimo, Robert A Weinberg
Oct 4, 2006·Cancer Metastasis Reviews·A Ben-Baruch
Nov 25, 2006·Nature Reviews. Immunology·Alberto MantovaniMassimo Locati
Dec 14, 2006·Cancer Metastasis Reviews·Jianhua WangRussell S Taichman
Jan 11, 2007·Journal of Cellular Biochemistry·Derek C RadiskyMina J Bissell
Feb 3, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Juliana Croitoru-LamouryBruce J Brew
Aug 2, 2007·Expert Opinion on Biological Therapy·Sonia C PicinichDebabrata Banerjee
Aug 7, 2007·International Journal of Hematology·Brett HallFrank Marini
Sep 25, 2007·Clinical & Experimental Metastasis·Adit Ben-Baruch
Oct 5, 2007·Critical Reviews in Oncology/hematology·Paola AllavenaAlberto Mantovani

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Citations

Dec 23, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Adit Ben-Baruch
Apr 2, 2011·The Journal of Biological Chemistry·Sherine F ElsawaMartin E Fernandez-Zapico
Apr 26, 2012·Molecular Cancer Therapeutics·Courtney R LaValleQ Jane Wang
Jan 14, 2011·Molecular Cancer Research : MCR·Mie IchikawaGeetha Srikrishna
Apr 6, 2011·Immunotherapy·Lindzy F DodsonPeter Goedegebuure
Nov 8, 2011·Immunotherapy·Judith LeiboviciJudith Sinai
Nov 3, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lauren E Woodard, Sridhar Nimmagadda
Jul 16, 2013·Oncogene·L BorsigM Heikenwalder
Oct 12, 2012·Molecular Biology Reports·Marla Karine AmaranteMaria Angelica Ehara Watanabe
Jun 16, 2012·Clinical and Experimental Medicine·Karen Brajão de OliveiraMaria Angelica Ehara Watanabe
Feb 11, 2012·Clinical & Experimental Metastasis·Daniela Spano, Massimo Zollo
Sep 4, 2015·International Journal of Cancer. Journal International Du Cancer·Jinxu FangPin Wang
Feb 6, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ido D WeissOri Wald
Jun 29, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zu-Yau LinWan-Long Chuang
Nov 1, 2011·Experimental Cell Research·Naofumi Mukaida, Tomohisa Baba
Jun 15, 2011·Differentiation; Research in Biological Diversity·Isaiah G Schauer, David R Rowley
Oct 3, 2015·The Journal of Surgical Research·Junichi MurakamiKimikazu Hamano
Jul 7, 2015·Immunology Letters·Lizzia Raffaghello, Francesco Dazzi
Nov 21, 2012·International Journal of Cancer. Journal International Du Cancer·Sofia DepnerMargareta M Mueller
Feb 11, 2014·International Journal of Cancer. Journal International Du Cancer·Soichiro SasakiNaofumi Mukaida
Aug 5, 2014·Journal of Gastroenterology and Hepatology·Zu-Yau LinWan-Long Chuang
Mar 10, 2015·Molecular Cancer·Elena Tutunea-FatanPeeyush K Lala
Sep 23, 2014·Future Oncology·Cristiana TanaseMonica Neagu
Nov 19, 2014·International Journal of Cancer. Journal International Du Cancer·Katrin SobelPetra Boukamp
Mar 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fernando Vázquez-VillaJuan R de Los Toyos
Mar 3, 2012·Seminars in Cancer Biology·Eugene Lukanidin, Jonathan P Sleeman
Jul 25, 2012·Cancer Letters·Magali CastellsBettina Couderc
Apr 10, 2012·Seminars in Cancer Biology·François Lehembre, Urs Regenass

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