PMID: 16612466Apr 14, 2006Paper

Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
M A MoreiraA L Teixeira

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system. Although its etiology is unknown, the accumulation and activation of mononuclear cells in the central nervous system are crucial to its pathogenesis. Chemokines have been proposed to play a major role in the recruitment and activation of leukocytes in inflammatory sites. They are divided into subfamilies on the basis of the location of conserved cysteine residues. We determined the levels of some CC and CXC chemokines in the cerebrospinal fluid (CSF) of 23 relapsing-remitting MS patients under interferon-ss-1a therapy and 16 control subjects using ELISA. MS patients were categorized as having active or stable disease. CXCL10 was significantly increased in the CSF of active MS patients (mean +/- SEM, 369.5 +/- 69.3 pg/mL) when compared with controls (178.5 +/- 29.1 pg/mL, P < 0.05). CSF levels of CCL2 were significantly lower in active MS (144.7 +/- 14.4 pg/mL) than in controls (237.1 +/- 16.4 pg/mL, P < 0.01). There was no difference in the concentration of CCL2 and CXCL10 between patients with stable MS and controls. CCL5 was not detectable in the CSF of most patients or controls. The qualitative and quantitative differ...Continue Reading

References

Dec 1, 1992·Arquivos de neuro-psiquiatria·M A Lana-Peixoto, M I Lana-Peixoto
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Mar 17, 1999·The Journal of Clinical Investigation·T L SørensenR M Ransohoff
Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Mar 29, 2001·Nature Immunology·C R Mackay
Feb 28, 2002·Journal of the Neurological Sciences·Elio ScarpiniGuglielmo Scarlato
Nov 9, 2002·The Journal of Infectious Diseases·R M Ransohoff
Aug 12, 2003·Brain Research Bulletin·Barbara Kornek, Hans Lassmann
Aug 12, 2003·Brain Research Bulletin·F Sellebjerg, T L Sørensen
Mar 17, 2004·Journal of Neuroimmunology·Koichi NarikawaYasuto Itoyama
Mar 24, 2004·Trends in Immunology·Hans Lassmann, Richard M Ransohoff
Apr 7, 2004·The Journal of Clinical Investigation·David A Hafler
Apr 23, 2004·Trends in Immunology·Bernhard MoserPius Loetscher
Jun 8, 2004·Brain : a Journal of Neurology·Bibiana Bielekova, Roland Martin
Dec 23, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H Bartosik-Psujek, Z Stelmasiak
Apr 19, 2005·Journal of Neuroimmunology·Adriana Carvalho dos SantosJuliana Carvalho-Tavares

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Citations

Jun 16, 2012·Immunology Letters·Peter J Nelson, Mauro M Teixeira
Mar 7, 2012·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Rodrigo Grassi-OliveiraMoisés Evandro Bauer
Jul 8, 2010·Journal of Neuroimmunology·Marloes van ZwamLeonie A Boven
Mar 31, 2009·Arquivos de neuro-psiquiatria·David Henrique RodriguesAntonio Lucio Teixeira
Jul 20, 2018·Journal of Neuroinflammation·Irene HåkanssonJan Ernerudh
Jul 28, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Cristiano NotoElisa Brietzke
Jul 1, 2013·Hepatology International·Lin-Jiao ChenJun-Qi Niu

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