Chemomodulatory effects of Azadirachta indica on the hepatic status of skin tumor bearing mice

Phytotherapy Research : PTR
Ashwani KoulSubhash Chander Gangar

Abstract

The liver plays an important role in the modulation of the process of carcinogenesis, as it is the primary site for the biotransformation of xenobiotics including carcinogens as well as anticancer drugs. The present study was designed to evaluate the biochemical alterations occurring in the liver of 7,12-dimethylbenz(a)anthracene (DMBA) induced skin tumor bearing male Balb/c mice and their modulation by aqueous Azadirachta indica leaf extract (AAILE). It was observed that skin tumor induction caused hepatic damage characterized by a decreased hepatosomatic index and significantly increased (p < 0.001) activities of the hepatic tissue injury marker enzymes, namely alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase. However, upon treatment with AAILE, the above-mentioned alterations, including the increased activities of hepatic tissue injury marker enzymes, were significantly reversed, which signified the hepato-protective efficacy of Azadirachta indica. Increased oxidative stress was also observed in the hepatic tissue of skin tumor bearing mice as revealed by a significant increase (p < 0.001) in lipid peroxidation levels and a decrease in reduced glutathione contents and activities of various antiox...Continue Reading

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Citations

Nov 6, 2018·Journal of Evidence-based Integrative Medicine·Regina Appiah-OpongAlexander K Nyarko
Jun 24, 2008·Phytotherapy Research : PTR·Praveen RishiAshwani Koul
Mar 27, 2015·International Journal of Dermatology·Tina MaverSamo Kreft
May 24, 2006·World Journal of Gastroenterology : WJG·Subhash Chander GangarAshwani Koul
Jul 1, 2009·Environmental Toxicology and Pharmacology·Lakshmanan VellaichamyLinsa Mary Alias

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