PMID: 8580786Dec 1, 1995Paper

Chemoprevention by melatonin and combined melatonin-tamoxifen therapy of second generation nitroso-methylurea-induced mammary tumours in rats

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
A KothariL Kothari

Abstract

Melatonin, an indole of pineal origin, is known to have an oncostatic effect on carcinogen-induced rat mammary tumours. We have assessed for the first time, the efficacy of melatonin alone and in combination with a sub-optimal dose of tamoxifen, a partial oestrogen antagonist, on N-nitroso-N-methylurea-induced rat mammary tumours. Both these agents were administered to Sprague-Dawley rats following excision of the primary tumours. Melatonin (200 micrograms/day/rat) at the given dose level could significantly suppress the appearance of second generation mammary tumours and the latency period of tumour appearance was also significantly increased (P < 0.001) as compared to vehicle-treated animals. Tamoxifen (60 micrograms/week/rat) does not suppress the development of second generation mammary tumours. Co-administration of melatonin and low dose of tamoxifen had no additive or synergistic effect on the prevention of second generation of mammary tumours. The results warrant the clinical evaluation of melatonin for chemoprevention and adjuvant therapy.

Citations

Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R G Mehta
Jun 7, 2003·Critical Reviews in Oncology/hematology·Vladimir N Anisimov
Sep 25, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chao-Cheng WangStephen Barnes
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir N AnisimovIrina A Vinogradova
Apr 15, 2000·Frontiers in Neuroendocrinology·S Cos, E J Sánchez-Barceló
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elaheh NooshinfarMohammad Esmaeil Akbari
May 3, 2003·The British Journal of Nutrition·Antti A HoikkalaKristiina Wähälä
Oct 18, 2001·Journal of the American College of Nutrition·K D Setchell
Dec 6, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·V-M S RamanujamLee-Jane W Lu

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