Chemoprevention of azoxymethane-induced rat colon carcinogenesis by dietary capsaicin and rotenone

International Journal of Oncology
S YoshitaniS Takashima

Abstract

The modifying effects of dietary administration of capsaicin, which is the principal pungent capsicum fruit, and rotenone, which is a naturally occurring pesticide derived from Derris and Lonchorcarpus species, on azoxymethane (AOM)-induced colon tumorigenesis were investigated in male F344 rats. Gavage with capsaicin and rotenone significantly elevated phase II enzymes, glutathione S-transferase (GST) and quinone reductase (QR), in the liver and colon. In an aberrant crypt foci (ACF) bioassay, feeding of capsaicin and rotenone at a dose of 500 ppm for 4 weeks significantly inhibited ACF formation induced by AOM (20 mg/kg body weight, once a week for 2 weeks). In a subsequent long-term study designed to confirm the protective effects of both compounds on ACF development, one group was treated with AOM alone and four other groups received the carcinogen treatment plus diets containing 500 ppm test compounds for 4 weeks (initiation phase) and for 34 weeks (post-initiation phase). Two groups were treated with capsaicin or rotenone alone (500 ppm in diet) and one group was maintained on the basal diet. At the termination of the study, dietary exposure of capsaicin during the initiation phase was found to significantly reduce the in...Continue Reading

Citations

Nov 25, 2005·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Makoto Hayashi, Noriho Tanaka
May 14, 2020·Nutrition and Cancer·Luis Manuel Sarmiento-MachadoLuís Fernando Barbisan
Jan 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·George Denis Alexandru PopescuConstantin Caruntu

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