PMID: 22583403May 16, 2012Paper

Chemoprevention of breast cancer by dietary compounds

Anti-cancer Agents in Medicinal Chemistry
Aditi S VadodkarChendil Damodaran

Abstract

Breast cancer is the leading cause of cancer-related deaths in women in the United States and many other countries. There is an immediate need for more effective and less toxic therapeutic and preventive strategies for many cancers, especially for breast cancer. Natural products are being tested with a hope of identifying novel potent molecules as anticancer agents. Phytochemicals and dietary compounds have been used for the treatment of various illnesses throughout history due to their safety, low toxicity, and general availability. Currently, many active phytochemicals are in clinical trials. Preclinical and clinical studies have indicated that daily consumption of dietary phytochemicals reduces the risk of several cancers. Phytochemicals can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes, by regulating inflammatory/proliferative signaling pathways, and by inducing apoptosis. This review article describes some of the potential natural cancer preventive compounds, along with a mechanistic discussion of their interactions with key cellular signal transduction pathways as well as their contribution to the suppression of breast cancer cell growth.

Citations

Jan 24, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Anupam Bishayee, Animesh Mandal
Nov 15, 2014·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Nisha R ParikhAnupam Bishayee
Nov 15, 2014·Current Colorectal Cancer Reports·Suman SumanChendil Damodaran
Jan 18, 2016·Seminars in Cancer Biology·Dona SinhaAnupam Bishayee
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