Chemoprevention of breast cancer by tamoxifen: risks and opportunities

Toxicology Letters
L L Smith, I N White

Abstract

The antioestrogen tamoxifen is of proven efficacy in inhibiting the growth of oestrogen receptor positive breast cancers in women. In rats, long-term dosing leads to the development of hepatocellular tumours. Tamoxifen in this species is a genotoxic carcinogen. Metabolic activation by cytochrome P450-dependent enzymes leads to DNA damage detectable by 32P-postlabelling. Factors important in the development of hepatocellular lesions were the nature and quantity of metabolism and promotion/progression of the DNA lesion by agents such as phenobarbital and cell proliferation. No evidence was found for tamoxifen-induced DNA damage in the livers of 7 women taking this drug therapeutically.

References

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Jan 1, 1994·Breast Cancer Research and Treatment·T J PowlesM Baum

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Citations

Jul 1, 1997·Trends in Pharmacological Sciences·A de Cupis, R E Favoni
Jun 8, 2001·The International Journal of Biochemistry & Cell Biology·F CaballeroE Vazquez
Dec 14, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Seul Min Choi, Byung Mu Lee
Nov 23, 2013·International Journal of Nanomedicine·Sangiliyandi GurunathanSabaratnam Vikineswary
Jul 1, 2009·International Journal of Molecular Sciences·Chengkang TangXiaojun Zhao
Mar 9, 2017·Frontiers in Chemistry·Mário R FelícioOctávio L Franco

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