Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus

Gastroenterology
Navtej S ButtarLawrence J Burgart

Abstract

Carcinogenesis in Barrett's esophagus (BE) is associated with an increased expression of cyclooxygenase (COX) 2. However, there has been no direct evidence that inhibition of COX-2 prevents cancer in BE. We studied the effect of MF-Tricyclic, a selective COX-2 inhibitor, on the development of BE and adenocarcinoma in a rat model. Four weeks after esophagojejunostomy, 105 Sprague-Dawley rats were randomized to a chow containing MF-Tricyclic or Sulindac, or a placebo. Ninety-six (92%) rats completed the study and were sacrificed at 28 +/- 2 weeks. The animals were assessed for the presence of cancer, tumor volume, BE, degree of inflammation, and COX-2 expression and activity. MF-Tricyclic and Sulindac reduced the relative risk of development of esophageal cancer by 55% (95% confidence interval [CI] = 43%-66%, P < 0.008) and by 79% (95% CI = 68%-87%, P < 0.001), respectively, compared with controls. No significant differences were noted in the risk of esophageal cancer between the MF-Tricyclic and the Sulindac group (P = 0.34). The median tumor volume was not significantly different among the 3 groups (P = 0.081). Moderate to severe degree of inflammation was significantly more common (P = 0.005) in the control compared with the M...Continue Reading

References

Feb 11, 1991·Annals of Surgery·J M StreitzE Watkins
Aug 7, 1986·The New England Journal of Medicine·S J Spechler, R K Goyal
Oct 3, 1985·The New England Journal of Medicine·A J CameronW S Payne
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·K SeibertP Isakson
Jun 1, 1993·The Annals of Thoracic Surgery·M PeraP C Pairolero
Jul 17, 1996·International Journal of Cancer. Journal International Du Cancer·K MiwaT Hattori
Nov 1, 1996·The Journal of Clinical Investigation·R C FitzgeraldG Triadafilopoulos
Dec 1, 1996·Journal of Gastroenterology·R N DuBois, W E Smalley
Aug 1, 1996·Surgical Oncology·G W ClarkP D Carey
May 1, 1997·The Journal of Clinical Investigation·H ShengR N DuBois
Feb 12, 1998·Proceedings of the Society for Experimental Biology and Medicine·K SubbaramaiahA J Dannenberg
Dec 8, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·M FeinT R DeMeester
Aug 10, 2000·Gastroenterology·N J ShaheenR S Sandler
Nov 23, 2000·The New England Journal of Medicine·C BombardierUNKNOWN VIGOR Study Group
Feb 24, 2001·Mayo Clinic Proceedings·N S Buttar, G W Falk
Aug 31, 2001·JAMA : the Journal of the American Medical Association·D MukherjeeE J Topol

❮ Previous
Next ❯

Citations

Mar 13, 2003·Clinical Journal of Oncology Nursing·Deanna Sanchez Yamamoto, Pamela Hallquist Viale
May 27, 2003·Cancer·Sergio VidalRicardo V Lloyd
Dec 3, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E I HeathUNKNOWN CBET Research Group
Feb 11, 2005·Current Opinion in Gastroenterology·Sanjeev Slehria, Prateek Sharma
Aug 2, 2005·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·L A Feagins, R F Souza
Mar 19, 2005·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R E Sampliner
Feb 2, 2006·International Journal of Cancer. Journal International Du Cancer·Vijayvel JayaprakashKirsten B Moysich
Oct 20, 2006·The British Journal of Surgery·M FeinK-H Fuchs
Oct 25, 2006·Alimentary Pharmacology & Therapeutics·S MehtaM Rhodes
Jun 22, 2007·The American Journal of Gastroenterology·Leon M G MoonsJohannes G Kusters
Sep 5, 2007·Alimentary Pharmacology & Therapeutics·A LanasJ M Pique
Oct 25, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Tomoharu MiyashitaJohn W Harmon
Sep 9, 2008·The American Journal of Gastroenterology·Chin HurG Scott Gazelle
Oct 11, 2008·The American Journal of Gastroenterology·Stephen E AttwoodJanusz A Jankowski
Oct 9, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P Lao-SirieixR C Fitzgerald
Aug 9, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A HindmarshM Rhodes
Mar 17, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Katherine S GarmanXiaoxin Chen
Mar 31, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A van de WinkelM P Peppelenbosch
Aug 21, 2013·Journal of Gastroenterology·Romy E VerbeekJantine W P M van Baal
Jan 5, 2014·BMC Gastroenterology·Hennie M J RoelofsWilbert H M Peters
Apr 3, 2020·Experimental & Molecular Medicine·Hyeongsun MoonAlexander D Borowsky
Mar 29, 2005·World Journal of Gastroenterology : WJG·Li MaQiu-Ning Zhang
Oct 16, 2004·World Journal of Gastroenterology : WJG·Jin-Hai WangAi-Li Zuo
Apr 2, 2003·Current Oncology Reports·Burkhard H A von RahdenJörg R Siewert
Jul 26, 2006·The American Journal of Gastroenterology·Sameh HannaPrateek Sharma
Jul 26, 2006·The American Journal of Gastroenterology·Daniel VallböhmerTom R DeMeester
Mar 29, 2008·The American Journal of Gastroenterology·Olorunseun O Ogunwobi, Ian L P Beales
Nov 24, 2004·The American Journal of Gastroenterology·Brenda C WesthoffPrateek Sharma
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Yuji AmanoYoshikazu Kinoshita
Dec 27, 2007·Yonsei Medical Journal·Sung Wook KimJung Il Suh
Apr 5, 2007·Journal of the National Cancer Institute·Elisabeth I HeathUNKNOWN Chemoprevention for Barrett's Esophagus Trial Research Group
Mar 20, 2010·Biochemical Society Transactions·Rhonda F Souza
Apr 15, 2009·Human Genetics·Massimiliano di Pietro, Rebecca C Fitzgerald
Sep 1, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Yan Li, Robert C G Martin
Jun 3, 2010·Nature Reviews. Gastroenterology & Hepatology·Rami J Badreddine, Kenneth K Wang
Jul 23, 2008·International Journal of Cancer. Journal International Du Cancer·Masaru ObaTakanori Hattori
Sep 1, 2008·Therapeutic Advances in Gastroenterology·Michael S Smith, Charles J Lightdale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Related Papers

The Journal of Surgical Research
W Brent KeelingMurray L Shames
Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
Z J ChengEero M A Mervaala
© 2022 Meta ULC. All rights reserved