PMID: 11921198Mar 29, 2002Paper

Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats

Environmental and Molecular Mutagenesis
Masao HiroseTomoyuki Shirai

Abstract

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is one of the most prevalent carcinogenic heterocyclic amines in the environment, targeting the colon, prostate, pancreas, and mammary gland in rodents. Chemopreventive effects of synthetic and naturally occurring compounds on PhIP-induced rat mammary carcinogenesis were investigated in a series of experiments. In a PhIP feeding model, groups of 20-21 female F344 rats each, were treated with 0.02% PhIP alone or PhIP plus 0.5% 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), 1% green tea catechins, 1% alpha-tocopherol, 0.1% ellagic acid, or 1% chlorophyllin, each in the diet, or 0.1% caffeine in drinking water for 52 weeks. To assess the mechanism of HTHQ and caffeine inhibition of PhIP-induced carcinogenesis, effects of these compound on the in vitro metabolic activation of PhIP were examined in the presence of S9 mix. In the next series of experiments, the PhIP intragastric dose model was applied to allow separate investigation of the effects of chemicals during the initiation and postinitiation periods. In these experiments, female Sprague-Dawley rats were given eight intragastric doses of 100 mg/kg body weight during the first 4-8 weeks for initiation. Either during initiat...Continue Reading

References

Mar 1, 1988·Cancer·H M Phelps, C E Phelps
Apr 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T M KnightR Doll
Dec 15, 1994·International Journal of Cancer. Journal International Du Cancer·P KnektA Aromaa
Mar 1, 1993·Environmental Health Perspectives·K WakabayashiM Nagao
Sep 3, 1998·Mutation Research·J H WeisburgerB Pittman
Apr 3, 1999·International Journal of Cancer. Journal International Du Cancer·M L SlatteryJ D Potter

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Citations

Jan 1, 2003·Environmental Health and Preventive Medicine·John H Weisburger
Oct 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Fan LeiLi-Jun Du
Mar 18, 2004·Breast Cancer Research and Treatment·Takashi YuriAiro Tsubura
Sep 15, 2009·Carcinogenesis·Jihyeung JuChung S Yang
Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E González de MejíaS Villa-Treviño
Dec 25, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M TasakiA Nishikawa
Mar 30, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gye-Hyeong WooMasao Hirose
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Shigeyuki SugieHideki Mori
Mar 27, 2016·Seminars in Cancer Biology·Min Ji BakNanjoo Suh
Sep 2, 2006·Life Sciences·Emma C StuartRhonda J Rosengren
Nov 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tammie J McQuistanGeorge S Bailey
Aug 15, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nathan S BryanPaolo Boffetta
Aug 13, 2014·World Journal of Clinical Oncology·Min-Jing LiYang-Fu Jiang
May 25, 2010·Journal of Food Science·Kanithaporn Puangsombat, J Scott Smith
Jul 5, 2019·Integrative Cancer Therapies·Yi-Hsuan HsiaoShun-Fa Yang
Jan 15, 2014·The Journal of Toxicological Sciences·Takeshi ToyodaKumiko Ogawa
Aug 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yi-Ting WangJei-Fu Shaw
Nov 19, 2020·Food & Function·Sara Shojaei-ZarghaniSaber Azami-Aghdash
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Elvira Gonzalez de MejiaHideka Kobayashi

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