PMID: 18409338Apr 16, 2008Paper

Chemoprevention of tobacco-related lung cancer by cruciferous vegetable

Przegla̧d lekarski
Maciej Balcerek

Abstract

Lung cancer is the most common malignant disease in the world and the major cause of death from cancers. Around 80-90% of all human lung cancers are related to cigarette smoke. Tobacco smoke contains at least 60 carcinogens capable of causing tumors, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and polycyclic aromatic hydrocarbons (PAH) are among the most prominent pulmonary carcinogens. Prevention is the most effective way to reduce lung cancer mortality. Chemoprevention is a cancer preventive strategy to inhibit, delay or reverse carcinogenesis using naturally occurring or synthetic chemical agents. A number of epidemiological studies have shown an inverse relationship between cruciferous vegetable consumption and cancer, especially those of lung and stomach. Crucifers, such as broccoli, cauliflower, brussel sprouts and cabbage, contain a family of secondary plant metabolites known as glucosinolates, which are unique to these vegetables. Upon hydrolysis, glucosinolates yield a number of breakdown products, mostly isothiocyanates, with supposed chemopreventive properties, as shown in animal experiments. It appears that significant portion of the chemopreventive effects of isothiocyanates may be associated with the...Continue Reading

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