Chemoprevention Uptake for Breast Cancer Risk Reduction Varies by Risk Factor

Annals of Surgical Oncology
Meghan R FlanaganMelissa L Pilewskie

Abstract

The efficacy of chemoprevention for breast cancer risk reduction has been demonstrated in randomized controlled trials; however, use remains low. We sought to determine whether uptake differed by risk factors, and to identify reasons for refusal and termination. Women seen in a high-risk clinic from October 2014 to June 2017 considered eligible for chemoprevention (history of lobular carcinoma in situ, atypia, family history of breast/ovarian cancer, genetic mutation, or history of chest wall radiation) were retrospectively identified. Breast cancer risk factors were compared among those with and without chemoprevention use, and compliance was noted. Overall, 1506 women were identified, 24% with prior/current chemoprevention use. Women ≥ 50 years of age were more likely to use chemoprevention than women < 50 years of age (28% vs. 11%, p < 0.001). Chemoprevention use by risk factor ranged from 7 to 40%. Having multiple risk factors did not increase use. Significant variation by risk factor was present among women ≥ 50 years of age (p < 0.001), but not among women < 50 years of age (p = 0.1). Among women with a documented discussion regarding chemoprevention (575/1141), fear of adverse effects was the most common refusal reason (...Continue Reading

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Citations

May 19, 2019·Annals of Surgical Oncology·Meghan R Flanagan, Melissa L Pilewskie
Jan 4, 2020·Annals of Surgical Oncology·Christina A MinamiMelissa L Pilewskie
Feb 25, 2019·Annals of Surgical Oncology·Marie E WoodIsabelle Bedrosian
Apr 5, 2020·Annals of Surgical Oncology·Christina Minami, Melissa L Pilewskie
Jun 9, 2021·The Journal of Surgical Research·Malcolm SuSarah Tevis
Jun 12, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patricia A ThompsonAlison T Stopeck

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