Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N-nitrosobis(2-oxopropyl)amine

Japanese Journal of Cancer Research : Gann
Akiyoshi NishikawaY Hayashi

Abstract

The chemopreventive effects of 3-phenylpropyl isothiocyanate (PPITC) were investigated in N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamsters. A total of 120 female 5-week-old hamsters were divided into 6 groups. Animals in groups 1-3, each consisting of 30 hamsters, were twice sc injected 7 days apart as an initiation treatment. Hamsters in groups 1 and 2 were respectively given 100 microM and 10 microM of PPITC by gavage 2 h prior to each BOP treatment. Animals in group 3 were treated with BOP alone, serving as an initiation-positive control. Animals in groups 4-6, each consisting of 10 hamsters, were given 100 microM or 10microM of PPITC alone, or non-treated, thus being available as matched negative controls to groups 1-3. At termination (experimental week 51 after the first BOP injection), the incidences of lung adenomas and/or adenocarcinomas were significantly decreased in groups 1 and 2 as compared to the group 3 value (p<0.01). The combined lung tumor incidences were inhibited by 94% and 59% at 100 and 10 microM doses, respectively. The inhibitory effects of PPITC were thus dose-dependent. The data for multiplicity of lung tumors dramatically illustrated the inhibitory effects of PPITC, and there were also statisti...Continue Reading

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