PMID: 25743804Mar 7, 2015Paper

Chemopreventive effects of hydatid disease on experimental breast cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Ahmet AltunMustafa Turan

Abstract

Breast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. In this study, we aimed to investigate protective role of hydatid disease against breast cancer. Twenty Wistar rats were divided into two groups of 10 rats each Group I (control) and Group II. In Group II intraperitoneal hydatidosis was performed. Then DMBA was applied to mammary tissues of all rats. Immunohistochemistry studies for Ki-67 and S-100 in the tumoral tissue sections of DMBA induced mammary tumor in rats were performed. TUNEL Assay was used to detect apoptotic cells of tumoral tissue. In vivo anticancer activity testing was carried out by preventing the tumorigenesis by DMBA in mammary tissue of rats. The expressions of the Ki-67 and S-100 protein decreased in rats who had Hydatid Disease (HD) (Group II), compared with the control rats (Group I). TUNEL positive cells were higher in rats with HD (Group II), compared with the control rats (Group I). In vivo studies showed that HD prevented the tumorigenesis by DMBA in mammary tissue of rats with 50 percent.In the light of the evidence the present study showed...Continue Reading

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Citations

Oct 15, 2019·Frontiers in Pharmacology·Wang GuanJinxin Zhang
Mar 30, 2018·Frontiers in Medicine·Shiwanthi L Ranasinghe, Donald P McManus
Sep 14, 2019·International Journal of Preventive Medicine·Shima DaneshpourHossein Yousofi Darani

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