Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: an apoptosome study.

Journal of Gastrointestinal Cancer
Vivek VaishSankar Nath Sanyal

Abstract

Apoptosis is a highly regulated mechanism of cell death where pro-apoptotic proteins and caspases play an important role. Activation of pro-caspases at a definite time is essential to control the whole caspase cascade. Mitochondrion contains some pro-apoptotic proteins, which need to come out in cytoplasm for apoptotic function such as Cytochrome c (Cyt c), while the Bcl-2 protein family works as the guard of mitochondrial membrane and prevents the escape of Cyt c. Once Cyt c is out in cytoplasm, it binds with Apaf-1 (another pro-apoptotic protein also essential for proper cell differentiation) and pro-caspase-9, forming the Apoptosome complex. In this study, the role of two non-steroidal anti-inflammatory drugs (NSAIDs), Diclofenac and Celecoxib, in experimentally induced early neoplasm of colon via apoptosome mechanism had been studied. It has been recognized that the prolonged use of NSAIDs has its effect on reducing the risk of colorectal cancer through apoptotic pathways. However, the role of NSAIDs in respect of apoptosome is not clear. Western blotting and immunohistochemistry were performed, along with morphological and histological analysis. According to the expression levels of Cytochrome c, Apaf-1, Caspases, and Bcl-...Continue Reading

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Citations

Nov 15, 2012·Cell Biochemistry and Biophysics·Vivek VaishSankar Nath Sanyal
Oct 13, 2011·Molecular and Cellular Biochemistry·Manpreet Kaur SainiSankar Nath Sanyal
Mar 22, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hilal GungorHatice Eroksuz

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