Chemopreventive effects of taurine on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats

Japanese Journal of Cancer Research : Gann
K OkamotoH Mori

Abstract

Modifying effects of taurine, a naturally occurring organosulfur compound, on diethylnitrosamine (DEN) and phenobarbital (PB)-induced hepatocarcinogenesis were examined in rats. Male F344 rats, 5 weeks old, were divided into 8 groups. Rats of groups 1 through 5 were given i.p. injections of DEN (100 mg/kg body weight) once a week for 3 weeks from one week after the start of the experiment. Of them, animals of group 2 received taurine mixed in a basal diet at a concentration of 2000 ppm for the initial 4 weeks, and those of groups 3 and 5 were given the agent starting 4 weeks after the beginning of the experiment until the end (24 weeks). Rats in groups 1, 4, 7 and 8 were kept on the basal diet throughout the experiment (24 weeks). Group 6 was given taurine throughout the experiment and group 8 was treated as a vehicle control. Animals of groups 1,2, 3 and 7 received PB in drinking water at a dose of 500 ppm from one week after the end of carcinogen or vehicle treatment. Liver neoplasms were recognized only in DEN-treated groups. The incidence and average number of liver neoplasms of group 3 were significantly lower than those of group 1. The number of glutathione S-transferase placental form (GST-P)-positive foci of group 2 or ...Continue Reading

References

Jan 1, 1992·Nutrition and Health·S Mizushima, Y Yamori
May 3, 1990·European Journal of Pharmacology·M A PettyG F DiFrancesco
Jan 1, 1989·Epidemiologic Reviews·J L Freudenheim, S Graham
Nov 15, 1988·The Biochemical Journal·O I AruomaJ Butler
Mar 1, 1986·The Biochemical Journal·A E Pegg
Jan 1, 1988·Advances in Enzyme Regulation·J KuiperT J Van Berkel
Nov 1, 1985·Journal of the National Cancer Institute·H F PiersonM Rabinovitz
Jan 1, 1983·Epidemiologic Reviews·S Graham
Mar 15, 1993·Biochemical and Biophysical Research Communications·H TrachtmanR S Bienkowski

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Citations

Oct 13, 1999·Mutation Research·H MoriT Tanaka
May 4, 2021·Frontiers in Cell and Developmental Biology·Xiaodan HouQiong Li

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