Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice

Carcinogenesis
C Duperron, A Castonguay

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs. In this study, we demonstrated the efficacy of aspirin to inhibit lung tumorigenesis in A/J mice. Lung tumors (9.9 tumors/mouse) were induced by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), administered in drinking water between week 0 and week +7. Groups of mice were fed sulindac (123 mg/kg diet), acetylsalicylic acid (ASA; 294 mg/kg), non-buffered Aspirin (294 mg/kg) or buffered Aspirin (294 mg/kg) in AIN-76A diet from week -2 to the end of the bioassay (week +23). These doses are comparable to the maximal doses recommended for humans. ASA and non-buffered Aspirin were the most effective inhibitors and reduced lung multiplicities by 60 and 62%, respectively. Sulindac inhibited lung tumor multiplicity by 52%. Inhibition by buffered Aspirin was not statistically significant. We evaluated the efficacies of NSAIDs to inhibit NNK activation by h1A2 v2 cells expressing human P-450 1A2. Salicylates, at doses of 500 microM and 1 mM, had no effect on NNK activation. Sulindac and its sulfide and sulfone metabolites (1 mM) inhibited NNK metabolism by 90, 92 and 65%, respectively. We observed a 76% inhibit...Continue Reading

Citations

Dec 26, 2007·Pathology Oncology Research : POR·Bing XinHideki Mizunuma
Jun 11, 2002·Biochemical and Biophysical Research Communications·C Susan Hsu, Yunbo Li
Apr 11, 2001·Urology·T L DeWeeseL J Marnett
Jun 8, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A M Malkinson
Dec 25, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C M RichardsonKenneth J O'Byrne
May 24, 2000·Cancer Letters·T W MoodyA L Goldstein
Nov 27, 2002·Surgical Oncology·Jiang Liu, Michael R Johnston
Jun 25, 2009·Nature Reviews. Cancer·Stephen S HechtDorothy K Hatsukami
Aug 22, 2002·Nature Reviews. Cancer·Hildegard M Schuller
Sep 28, 2005·The Journal of Experimental Medicine·Paulo C RodriguezAugusto C Ochoa
Apr 11, 2009·Carcinogenesis·Stephanie T Dance-BarnesMark Steven Miller
Feb 21, 2002·Journal of the National Cancer Institute·Michael J ThunCarlo Patrono
Feb 24, 2001·Drug Metabolism and Drug Interactions·M Cuendet, J M Pezzuto
Feb 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nikhil M VadMajid Y Moridani
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·E D ReisE A Fisher
Oct 20, 2007·Expert Review of Anticancer Therapy·Katherine A PeeblesSteven M Dubinett
Jul 11, 1998·Experimental Lung Research·A CastonguayG Jalbert
Mar 16, 2005·Experimental Lung Research·Alvin M Malkinson
Nov 22, 2012·Expert Opinion on Investigational Drugs·Konstantine DragnevRonald Lubet
Mar 11, 2003·Scandinavian Cardiovascular Journal : SCJ·Mette OlesenErling Falk
Dec 25, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Paul J LimburgUNKNOWN Cancer Prevention Network
Nov 5, 2003·Clinical Lung Cancer·Santiago Ballaz, James L Mulshine
Mar 6, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Miki Niikawa, Hisamitsu Nagase
Nov 4, 2005·Pediatric Pulmonology·Gerene M Denning, Lynn L Stoll
Nov 7, 2007·International Journal of Cancer. Journal International Du Cancer·Henry P CiolinoGrace Chao Yeh
Jun 19, 2004·The International Journal of Biochemistry & Cell Biology·P SaccaE Vazquez
Apr 8, 2004·Cancer Detection and Prevention·Kemal KismetAygün Ercan
Nov 18, 2015·BMC Cancer·Úna C Mc MenaminLiam M Murray
Jan 15, 1999·Hematology/oncology Clinics of North America·M You, G Bergman
Jun 9, 2005·The Journal of Thoracic and Cardiovascular Surgery·Eric M SieversRoss M Bremner
Oct 8, 2003·The Annals of Thoracic Surgery·J Esteban CastelaoRoss M Bremner

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