Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat

Cancer Research
Laurie A DavidsonRobert S Chapkin

Abstract

The mechanisms by which n-3 polyunsaturated fatty acids (PUFAs) decrease colon tumor formation have not been fully elucidated. Examination of genes up- or down-regulated at various stages of tumor development via the monitoring of gene expression relationships will help to determine the biological processes ultimately responsible for the protective effects of n-3 PUFA. Therefore, using a 3 x 2 x 2 factorial design, we used Codelink DNA microarrays containing approximately 9000 genes to help decipher the global changes in colonocyte gene expression profiles in carcinogen-injected Sprague Dawley rats. Animals were assigned to three dietary treatments differing only in the type of fat (corn oil/n-6 PUFA, fish oil/n-3 PUFA, or olive oil/n-9 monounsaturated fatty acid), two treatments (injection with the carcinogen azoxymethane or with saline), and two time points (12 hours and 10 weeks after first injection). Only the consumption of n-3 PUFA exerted a protective effect at the initiation (DNA adduct formation) and promotional (aberrant crypt foci) stages. Importantly, microarray analysis of colonocyte gene expression profiles discerned fundamental differences among animals treated with n-3 PUFA at both the 12 hours and 10-week time ...Continue Reading

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Citations

Jan 9, 2009·Apoptosis : an International Journal on Programmed Cell Death·Simona SeriniGabriella Calviello
Mar 17, 2011·Digestive Diseases and Sciences·Priyanka KachrooRobert S Chapkin
Aug 21, 2013·Current Gastroenterology Reports·N D TurnerR S Chapkin
Dec 16, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E EscrichL Grau
May 22, 2008·The British Journal of Nutrition·Robert S ChapkinJoanne R Lupton
Feb 24, 2009·Nutrition and Cancer·Ajay BommareddyChandradhar Dwivedi
Sep 10, 2005·Bioinformatics·Li-yu D LiuLaurie A Davidson
Nov 30, 2006·Current Opinion in Gastroenterology·Robert S ChapkinJoanne R Lupton
Mar 6, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert S ChapkinEdward R Dougherty
Sep 24, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jennifer M MonkRobert S Chapkin
Oct 22, 2009·Cancer Prevention Research·Laurie A DavidsonRobert S Chapkin
Apr 15, 2011·Cancer Prevention Research·Yang-Yi FanRobert S Chapkin
Dec 31, 2005·BMC Bioinformatics·Wei WuNaftali Kaminski
Nov 19, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Norihiro KatoSubrina Jesmin
Sep 27, 2008·PLoS Computational Biology·Xosé M Fernández-Suárez, Ewan Birney
Jul 5, 2012·PloS One·Harmony F TurkRobert S Chapkin
Oct 17, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Belma SkenderJirina Hofmanova
Nov 18, 2014·Current Colorectal Cancer Reports·Robert S ChapkinYang-Yi Fan
Mar 1, 2012·Current Nutrition Reports·Holly L NicastroJohn A Milner
Sep 14, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Audrey Y OtsukaIsmael D C G Silva
Mar 11, 2005·Expert Opinion on Therapeutic Targets·Ettore Bergamini
Aug 3, 2012·The Journal of Nutritional Biochemistry·Ting YangYan Zhang
Jul 30, 2011·Chemistry and Physics of Lipids·David N McMurrayRobert S Chapkin
Apr 30, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S Sánchez-FidalgoC Alarcón de la Lastra
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