Chemopreventive potential of green tea catechins in hepatocellular carcinoma

International Journal of Molecular Sciences
Masahito ShimizuHisataka Moriwaki

Abstract

Hepatocellular carcinoma (HCC), which is a common malignancy worldwide, usually develops in a cirrhotic liver due to hepatitis virus infection. Metabolic syndrome, which is frequently complicated by obesity and diabetes mellitus, is also a critical risk factor for liver carcinogenesis. Green tea catechins (GTCs) may possess potent anticancer and chemopreventive properties for a number of different malignancies, including liver cancer. Antioxidant and anti-inflammatory activities are key mechanisms through which GTCs prevent the development of neoplasms, and they also exert cancer chemopreventive effects by modulating several signaling transduction and metabolic pathways. Furthermore, GTCs are considered to be useful for the prevention of obesity- and metabolic syndrome-related carcinogenesis by improving metabolic disorders. Several interventional trials in humans have shown that GTCs may ameliorate metabolic abnormalities and prevent the development of precancerous lesions. The purpose of this article is to review the key mechanisms by which GTCs exert chemopreventive effects in liver carcinogenesis, focusing especially on their ability to inhibit receptor tyrosine kinases and improve metabolic abnormalities. We also review th...Continue Reading

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Citations

Jan 18, 2017·Nutrition and Cancer·Chen-Xu NiJun-Ping Zhang
Mar 24, 2016·International Journal of Molecular Sciences·Fang WangHua-Bin Li
Aug 24, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ju Dong Yang, Harmeet Malhi
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Dec 4, 2019·Japanese Journal of Clinical Oncology·Keitaro TanakaUNKNOWN Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
Feb 11, 2021·Pharmaceutics·Jacek RyszAnna Gluba-Brzózka
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nabil M Abdel-HamidDaniah Muneam Hamid

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Methods Mentioned

BETA
xenograft
xenografts

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