Abstract
Oxidative stress results from an imbalance in the production of reactive oxygen species (ROS) and cell's own antioxidant defenses that in part lead to numerous carcinogenesis. Several phytochemicals, derived from vegetables, fruits, herbs and spices, have demonstrated excellent chemopreventive properties against carcinogenesis by regulating the redox status of the cells during oxidative stress. I3C (indole-3-carbinol) and DIM (diindolylmethane) are the phytochemicals that are found in all types of cruciferous vegetables and demonstrated exceptional anti-cancer effects against hormone responsive cancers like breast, prostate and ovarian cancers. Novel analogs of I3C were designed to enhance the overall efficacy, particularly with respect to the therapeutic activity and oral bioavailability and that results in several patent applications on symptoms associated with endometriosis, vaginal neoplasia, cervical dysplasia and mastalgia. Likewise, DIM and its derivatives are patented for treatment and prevention of leiomyomas, HPV infection, respiratory syncytial virus, angiogenesis, atherosclerosis and anti-proliferative actions. On the other hand, phytochemicals in cardamom have not been explored in great details but limonene and cin...Continue Reading
Citations
Dec 21, 2011·The British Journal of Nutrition·Ila DasTapas Saha
Jul 18, 2012·Journal of Agricultural and Food Chemistry·Chia-Hua LiangTzung-Han Chou
Mar 13, 2012·Journal of Medicinal Food·Samir QiblawiDebasis Bagchi
Jan 17, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Kimberly G Blumenthal, John B Ziegler
Nov 26, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gyhye Yoo, Clinton D Allred
Jul 13, 2012·The Journal of Nutritional Biochemistry·Hongjing GuanQizhu Tang
Oct 15, 2011·Basic & Clinical Pharmacology & Toxicology·Yi-Chau LuChung-Ren Jan
Feb 11, 2015·Climacteric : the Journal of the International Menopause Society·F H Comhaire, H T Depypere
Aug 1, 2012·Journal of Receptor and Signal Transduction Research·Jeng-Yu TsaiChung-Ren Jan
Jun 19, 2013·Asian Pacific Journal of Tropical Medicine·Sweety Kumari, Abhijit Dutta
Apr 5, 2014·Biotechnology Advances·Michael SchnekenburgerMarc Diederich
Apr 28, 2016·Seminars in Cancer Biology·Eswar ShankarSanjay Gupta
May 28, 2016·Toxins·Geum-A LeeKyung-Chul Choi
Jun 24, 2017·Phytotherapy Research : PTR·Hina GulMuhammad Gulfraz
Aug 25, 2011·The Journal of Pharmacology and Experimental Therapeutics·Jie PingHui Wang
Sep 26, 2014·BioMed Research International·Neoh Hun Phuah, Noor Hasima Nagoor