PMID: 6967255Jul 1, 1980Paper

Chemoprophylaxis for Pneumocystis carinii pneumonitis: outcome of unstructured delivery

American Journal of Diseases of Children
R B WilberW T Hughes

Abstract

Sulfamethoxazole-trimethoprim was administered prophylactically to 786 patients judged to be at sufficient risk for development of Pneumocystis carinii pneumonitis. The selection of patients, administration of the agents, and surveillance for compliance were the responsibility of the attending oncologists rather than specialists in infectious diseases, as in an earlier trial at this center. The recommended dosage was trimethoprim, 150 mg/sq m/day, and sulfamethoxazole, 750 mg/sq m/day. Over a three-year study period, nine cases of P carinii pneumonitis occurred at this institution, with none attributable to drug failure. Adverse reactions, skin rashes mainly, were noted in 43 patients, and one patient died with Stevens-Johnson syndrome. These results confirm the efficacy of sulfamethoxazole-trimethoprim in preventing P carinii pneumonitis in childhood cancer patients and illustrate the feasibility of large-scale unstructured delivery of the combination to patients with malignant diseases frequently associated with this pneumonia.

Citations

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D M SchmatzM J Turner
Aug 1, 1983·Antimicrobial Agents and Chemotherapy·W T Hughes, B L Smith
Jan 1, 1991·International Journal of Antimicrobial Agents·I Varthalitis, F Meunier
Jul 1, 1981·The Journal of Pediatrics·R J LeggiadroW T Hughes
Nov 21, 2013·The Journal of Pediatrics·Désirée CaselliUNKNOWN Infectious Diseases Working Group of the Associazione Italiana Ematologia Oncologia Pediatrica
Mar 8, 2017·Journal of Pediatric Hematology/oncology·Rebecca ProudfootSophie Wilne
Jan 1, 1984·Cancer·W T Hughes, G Patterson
Oct 10, 1998·Journal of Paediatrics and Child Health·R J MassieP McIntyre
Sep 27, 2015·Archives of Disease in Childhood·Alison BoastAmanda Gwee
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·O P Settnes, J Genner
Jun 25, 1987·The New England Journal of Medicine·W T HughesL Lott
Jan 1, 1984·Journal of the Association of Pediatric Oncology Nurses·R F Kramer
Feb 27, 2021·Archives of Disease in Childhood·Rebecca Hilary Proudfoot, Bob Phillips
Oct 1, 1993·Cancer Treatment Reviews·I Varthalitis, F Meunier

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