PMID: 6164250Jan 1, 1981Paper

Chemoprophylaxis of depressions. An attempt to compare lithium with 5-hydroxytryptophan

Acta Psychiatrica Scandinavica. Supplementum
H M van Praag, S de Haan

Abstract

There are indications that the group of vital ('endogenous') depressions encompasses a subgroup with central 5-HT deficiency and that this factor contributes to the development of the (or some) depressive symptoms instead of resulting from them. In a majority of patients the suspected 5-HT deficiency persists even when the depressive symptoms have disappeared and the medication has been discontinued. This led us to the hypothesis that the disturbed central 5-HT metabolism is not a direct causal, but a predisposing factor. If this is true, then abolition of the suspected 5-HT deficiency, for example with the aid of 5-HTP, can be expected to have a prophylactic effect. This hypothesis was investigated in this study and confirmed. 5-HTP reduces the relapse rate in recurrent vital depressions with a unipolar and those with a bipolar course. This effect would seem to be most pronounced in patients whose disorders of central 5-HT metabolism are persistent. Tentatively it was concluded that 5-HTP seems to be inferior to lithium in bipolar patients and at least equivalent to lithium in unipolar patients. This problem, however, is still under investigation. 5-HTP prophylaxis is the first aimed (i.e. pathological substrate-oriented) type...Continue Reading

References

Mar 8, 1975·Lancet·M TrimbleC D Marsden
Dec 1, 1979·Psychiatry Research·H M van Praag, S de Haan
Feb 1, 1978·Biochemical Pharmacology·F SulserP L Mobley
Jan 1, 1977·British Journal of Clinical Pharmacology·J D Van ScheyenJ Korf
Jan 13, 1977·The New England Journal of Medicine·M H Van WoertM B Bowers
Jan 1, 1977·Neuropsychobiology·H M Van Praag
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Dec 1, 1965·Archives of General Psychiatry·W E Bunney, J M Davis

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Citations

Dec 1, 1982·Journal of Affective Disorders·H M Van Praag
Nov 7, 2015·Reviews in Endocrine & Metabolic Disorders·Giulia RastrelliMario Maggi
Jul 19, 2005·Pharmacology & Therapeutics·Erick H TurnerAaron D Blackwell
Jun 29, 2010·Journal of Affective Disorders·Nadia IovienoDavid Mischoulon
May 7, 2005·Metabolism: Clinical and Experimental·Madhu Kalia

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