PMID: 7027924May 1, 1981

Chemoprophylaxis with cefoxitin and cephalothin in orthopedic surgery: a comparison

Antimicrobial Agents and Chemotherapy
M B RosenfeldI Uredo


Forty-eight patients who underwent elective hip or knee surgery were randomly divided into two groups. A total of 22 patients received a single 1-g preoperative bolus of cefoxitin, and 26 patients received a single 1-g preoperative dose of cephalothin. At various time intervals, serum and bone samples were taken during the operative procedure. Our data indicated that whereas serum levels of cefoxitin and cephalothin were maintained for at least 2h at levels capable of inhibiting most gram-positive cocci and many gram-negative rods, bone levels of cefoxitin rather rapid decay over a 2-h period. Moreover, in only 58% of the entire cephalothin-treated group were bone levels detectable and then only at a concentration that would inhibited gram-positive cocci. No significant morbidity was observed in either treatment group.


Jan 1, 1979·Reviews of Infectious Diseases·J J SchrogieC M Martin
Jun 1, 1976·Antimicrobial Agents and Chemotherapy·L D SabathM Finland
Mar 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·D O KanyuckR C Anderson


Apr 1, 1989·American Journal of Surgery·B J GuglielmoR J Stoney

Related Concepts

Bacterial Infections
Skeletal Bone
Clinical Trials
Double-Blind Method
Hip Region Structure
Orthopedic Surgery (Discipline)
Surgical Wound Infection

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