Chemoprophylaxis with ciprofloxacin in ovarian cancer patients receiving paclitaxel: a randomized trial

Gynecologic Oncology
J W CarlsonL J Copeland

Abstract

The objective of this study was to evaluate the efficacy of oral ciprofloxacin in preventing febrile morbidity superimposed on the neutropenia induced from a paclitaxel regimen in ovarian cancer patients. Eligible patients received paclitaxel at doses of 135 to 175 mg/m2 alone or in combination with a platinum agent. They were randomized to either an observation (control) group or a ciprofloxacin prophylaxis group. Patients in the ciprofloxacin group received 500 mg ciprofloxacin orally twice a day once the absolute neutrophil count (ANC) was less than 500/mm3 and continued until the ANC was greater than 1000/mm3. Ninety patients were enrolled between the control (n = 45) and ciprofloxacin (n = 45) groups. They received 371 cycles of a paclitaxel-based regimen with 177 and 194 cycles in the control and ciprofloxacin groups, respectively. Ciprofloxacin prophylaxis was prescribed for 138 (71%) of the cycles in the ciprofloxacin group and was given for a mean duration of 7.7 days per cycle. The groups were similar in disease status and risk factors for neutropenia. Fifteen patients in the control group developed febrile neutropenia versus 12 of those in the ciprofloxacin group (P = 0.69). The mean ANC and mean length of hospital s...Continue Reading

References

Sep 1, 1991·The Journal of Hospital Infection·R E Warren
Jul 1, 1989·Diagnostic Microbiology and Infectious Disease·J Klastersky
Jan 1, 1993·Cancer Treatment Reviews·R C Donehower, E K Rowinsky
Sep 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J Bow, A R Ronald

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Citations

Dec 20, 1999·The Journal of Antimicrobial Chemotherapy·K G Kerr
Aug 19, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M PaulL Leibovici
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Anat Gafter-GviliLeonard Leibovici
Sep 16, 2006·Cancer·Leonard LeiboviciWinfried V Kern

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