Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats

Chemico-biological Interactions
Gokhan CuceMehmet Akoz

Abstract

Cyclophosphamide (CP) has a range of adverse effects on liver tissue in humans and animals. Administering an antioxidant with CP might reduce such side effects. Therefore, we examined the role of vitamin E in CP-induced liver toxicity in rats. Male Wistar albino rats were divided into four groups, each of seven rats: control, CP only, CP + vitamin E, and vitamin E only groups. The rats were administered treatments intraperitoneally for 7 days. Then the serum malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) levels were determined while the livers were removed, tissue was prepared using routine histological procedures, sections were stained using hematoxylin and eosin, and the terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) method was applied. Histopathologically, CP caused hydropic degeneration, necrosis, pleomorphism, and mitotic activity. The number of TUNEL-positive cells and the MDA and ALT levels were significantly higher in the CP group. The antioxidant effects of vitamin E significantly decreased the number of TUNEL-positive cells and the ALT and MDA levels, and normalized the liver histopathology. CP induces apoptosis, has toxic ...Continue Reading

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Citations

Feb 18, 2016·Canadian Journal of Physiology and Pharmacology·Amani EttayaNajla Hfaiedh
Jun 17, 2016·Environmental Toxicology and Pharmacology·Amr A FouadWalid N Al-Melhim
Feb 9, 2017·Canadian Journal of Physiology and Pharmacology·Rasha E MostafaHanan A Ogaly
May 23, 2019·Journal of Biochemical and Molecular Toxicology·Bahareh HakiminiaAzadeh Moghaddas
Jul 2, 2020·Journal of Biochemical and Molecular Toxicology·Jayant PatwaGopabandhu Jena
Feb 20, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Mahsa Zarei, T Shivanandappa
Feb 17, 2021·Clinical and Experimental Pharmacology & Physiology·Hanaa WanasBasma Emad Aboulhoda

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