Chemoprotective effects of a protein from the red algae Porphyra yezoensis on acetaminophen-induced liver injury in rats

Phytotherapy Research : PTR
Hye-Jung HwangTaek-Jeong Nam

Abstract

Seaweeds contribute to the maintenance of health through their nutritional and medicinal properties. The effects of PYP, a 14 kDa protein isolated from a hot-water extract of the marine alga Porphyra yezoensis, on AAP-induced liver injury in rats was evaluated. AAP induced acute liver injury and AAP-induced hepatotoxicity is the leading cause of liver failure. In this study, male Sprague-Dawley rats were assigned to one of three treatment groups: control, AAP, or AAP + PYP. Compared with the control group, liver tissue from the AAP group showed increased levels of caspase-3 activity and DNA fragmentation, decreased levels of GSH and increased serum GOT/GPT levels. In contrast, treatment with AAP + PYP produced levels of caspase-3 activity, DNA fragmentation, GSH and GOT/GPT that matched the values seen in the control group. It is concluded that PYP may prevent AAP-induced liver injury.

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Citations

Dec 9, 2009·The British Journal of Nutrition·Yoon Jung YangMi Kyung Kim
Apr 5, 2014·Nutrition Reviews·Emma S BrownEmeir M McSorley
Oct 27, 2015·International Journal of Molecular Medicine·Hyun-Ah LeeTaek-Jeong Nam
Dec 15, 2015·Journal of Medicinal Food·Jin CaoXiming Xu
Jul 10, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hiroe GoTaek-Jeong Nam
Mar 19, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Renata GrespanRoberto Kenji Nakamura Cuman
Sep 4, 2012·European Journal of Pharmacology·Amr A FouadWafaey Gomaa
Oct 17, 2014·Preventive Nutrition and Food Science·Jae Kyeom KimEui-Cheol Shin
Feb 6, 2020·Experimental and Therapeutic Medicine·In-Hye KimTaek-Jeong Nam
Jun 30, 2016·International Journal of Molecular Medicine·Jeong-Wook ChoiTaek-Jeong Nam

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