Chemoprotective role of ethanol extract of Urtica urens L. against the toxicity of imidacloprid on endocrine disruption and ovarian morphometric in female rats, GC/MS analysis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Massara MzidTarek Rebai

Abstract

Imidacloprid (IMI) is a widely used in Tunisia and abroad, and high doses of IMI have been known to cause endocrine disruption. Some reports claim that Urtica urens L. (UU) can reduce toxicity thanks to it anti-inflammatory and antioxidant activities, but there is no scientific evidence justifying its use, which lets us think to its direct effect on the metabolism of the ovarian tissue. The present study was undertaken to evaluate the protective effect of UU against the toxicity of Confidor®, whose active substance is imidacloprid (IMI), in female rat, as well as the chemical compositions of UU ethanol (EtOH) extract by GC-MS. Female rats were divided into control group, 3 groups treated with IMI at 50, 200 or 300mg/kg/day and three groups co-treated with IMI (50, 200 or 300mg/kg/day)+100mg/kg/day of UU, for 60days. Blood samples were collected for the dosage of 17β-estradiol levels. Ovaries were removed for tissular dosage of malondialdehyde (MDA), advanced oxidation protein products (AOPP), glutathione (GSH), vitamin E, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx). Histological and histomorphometric examinations were performed as well. IMI caused an acute ovary injury, increased the ovary tissue...Continue Reading

Citations

Mar 28, 2018·Antonie van Leeuwenhoek·Chenyu PiaoWensheng Xiang
Sep 3, 2021·Chemosphere·Guo-Ping ZhaoGuo-Fang Pang

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