Chemoradiation for carcinoma of the cervix: advances and opportunities

Radiation Research
P J Eifel

Abstract

Although it is possible to cure many patients with locally advanced cervical cancer using radiation therapy alone, loco-regional relapse continues to be a component of most recurrences. To improve control rates, clinicians have investigated ways of combining chemotherapy and radiation for more than 30 years. Despite encouraging results from phase II trials of neoadjuvant chemotherapy, randomized trials failed to improve on the results with radiation therapy alone. For a number of reasons, early trials of concurrent chemoradiation were inconclusive. However, recent reports of five large prospective randomized trials demonstrated dramatic improvements in survival and local control rates when cisplatin-containing chemotherapy was given during radiation therapy. These results also suggest a number of avenues for future research.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·P J Eifel
Jun 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L SouhamiT R Silveira
Sep 1, 1990·Gynecologic Oncology·G ThomasB Black
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J OvergaardI Löftquist
Dec 1, 1974·American Journal of Obstetrics and Gynecology·M S PiverJ Webester
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J E ByfieldF Kulhanian
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·P Carde, F Laval
Apr 30, 1994·International Journal of Radiation Oncology, Biology, Physics·P J EifelM J Oswald
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F B StehmanW T Creasman
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S El-Sayed, N Nelson
Dec 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D R ChristieA O Langlands
Nov 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M CoppinL D Sullivan
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·F LeborgneJ Mezzera
Jul 15, 1997·International Journal of Radiation Oncology, Biology, Physics·E RakovitchP M Leung
Mar 24, 1999·Journal of the National Cancer Institute·C McNeil
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Sep 24, 1999·Hematology/oncology Clinics of North America·J Bourhis, J P Pignon
Sep 1, 1992·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M.H.N. TattersallM. Coppleson

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Citations

Sep 18, 2001·International Journal of Radiation Oncology, Biology, Physics·H M Vriesendorp
Jan 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H BartelinkM Verheij
Nov 10, 2001·BMJ : British Medical Journal·R P Symonds
Dec 5, 2000·Journal of Women's Health & Gender-based Medicine
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H-S RyuJ-H Kim
Jun 17, 2006·Cancer Investigation·Aaron C Spalding, Theodore S Lawrence
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H AbaliN Guler
Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H AbaliN Guler
Dec 29, 2006·Chemistry & Biodiversity·Mira JungAnatoly Dritschilo

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BETA
hysterectomy

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