Chemoradiation therapy for potentially resectable gastric cancer: clinical outcomes among patients who do not undergo planned surgery

International Journal of Radiation Oncology, Biology, Physics
Michelle M KimSunil Krishnan

Abstract

We retrospectively analyzed treatment outcomes among resectable gastric cancer patients treated preoperatively with chemoradiation therapy (CRT) but rendered ineligible for planned surgery because of clinical deterioration or development of overt metastatic disease. Between 1996 and 2004, 39 patients with potentially resectable gastric cancer received preoperative CRT but failed to undergo surgery. At baseline clinical staging, 33 (85%) patients had T3-T4 disease, and 27 (69%) patients had nodal involvement. Most patients received 45 Gy of radiotherapy with concurrent 5-fluorouracil-based chemotherapy. Twenty-one patients underwent induction chemotherapy before CRT. Actuarial times to local control (LC), distant control (DC), and overall survival (OS) were calculated by the Kaplan-Meier method. The cause for surgical ineligibility was development of metastatic disease (28 patients, 72%; predominantly peritoneal, 18 patients), poor performance status (5 patients, 13%), patient/physician preference (4 patients, 10%), and treatment-related death (2 patients, 5%). With a median follow-up of 8 months (range, 1-95 months), actuarial 1-year LC, DC, and OS were 46%, 12%, and 36%, respectively. Median LC and OS were 11.0 and 10.1 months...Continue Reading

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Citations

Mar 26, 2010·Journal of Cancer Research and Clinical Oncology·Hirofumi AsakuraTetsuo Nishimura
Feb 2, 2012·Langenbeck's Archives of Surgery·Teiji NakaHiroki Yamaue
Jul 25, 2009·Lancet·Henk H HartgrinkCornelis J H van de Velde
Apr 7, 2009·Gastroentérologie Clinique Et Biologique·P Michel
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Oct 19, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L CenicerosJ Rodríguez

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