Chemoradiotherapy for locally advanced lung cancer patients with interstitial lung abnormalities

Japanese Journal of Clinical Oncology
Hisao HigoKatsuyuki Kiura

Abstract

Although chemoradiotherapy for locally advanced lung cancer has the potential for cure, treatment is avoided in patients with interstitial lung disease because of the risk for severe radiation pneumonitis. Interstitial lung abnormalities (ILA) can be evaluated using high-resolution computed tomography (HRCT) to assess interstitial changes. In this study, we retrospectively examined the feasibility and efficacy of chemoradiotherapy for locally advanced lung cancer patients with ILA. Patients who underwent chemoradiotherapy for locally advanced lung cancer at Okayama University Hospital between 2012 and 2015 were reviewed retrospectively. HRCT prior to treatment was evaluated by one pulmonologist and two radiologists using a sequential reading method. Of the 77 patients enrolled in this study, ILA was present in 25 (32.5%) and indeterminate ILA in 24 patients; 28 patients did not have ILA. Desaturation at rest (SpO2 < 95%) and honeycombing on HRCT were not observed in ILA patients. Only one patient with ILA had a low vital capacity (%VC < 80%). Severe radiation pneumonitis (≥Grade 2) occurred in 36.0% of the patients with ILA, but it was controllable; Grade 4 or 5 was not observed. Multivariate analysis showed that >25% of the lu...Continue Reading

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Citations

Jul 28, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Myra van LaarJoost J C Verhoeff
Feb 28, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christopher D GoodmanUNKNOWN International Association for the Study of Lung Cancer Advanced Radiation Technology Committee
Nov 28, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Görkem TürkkanDirk De Ruysscher
Mar 19, 2021·Radiation Oncology·Haruki KobayashiToshiaki Takahashi
Jan 16, 2022·Insights Into Imaging·Roberta Eufrasia LeddaNicola Sverzellati

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