Chemoradiotherapy for T4 and/or M1 lymph node esophageal cancer: experience since 2000 at a high-volume center in Japan

International Journal of Clinical Oncology
Keiichi JinguKen Takeda

Abstract

To review data for patients with stage T4 and/or M1 lymph node (lym) esophageal cancer who have been treated with definitive chemoradiotherapy since 2000 at a high-volume center in Japan. We retrospectively reviewed all patients with T4 and/or M1 lym esophageal cancer who were treated by definitive chemoradiotherapy between 2000 and 2010. The eligibility criteria included (1) histopathologically proven esophageal cancer, (2) T4 and/or M1 lym (UICC 2002), (3) 20-79 years of age, (4) having undergone at least 1 cycle of concomitant chemotherapy, (5) having been irradiated with ≥ 50 Gy, and (6) having no other active malignant tumor during treatment. Toxicity was graded according to the Common Terminology Criteria for Adverse Events (CTCAE v3.0). Data from 128 patients (70 with clinical stage III, 58 with clinical stage IV) were used for analysis in this study. The median observation period for survivors was 46.3 months. The 2- and 4-year overall survival rates were 32.8 and 24.4 %, respectively. The overall survival of patients without M1 lym was significantly better than that of patients with Ml lym (4-year, 32.6 vs 11.7 %, log-rank test; p = 0.04). Overall survival in more recent patients (2006-2010) did not show improvement wh...Continue Reading

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Citations

Sep 14, 2016·The Annals of Thoracic Surgery·Sahar A SaddoughiMark S Allen
Oct 7, 2019·Esophagus : Official Journal of the Japan Esophageal Society·Masayuki WatanabeHisahiro Matsubara
Mar 14, 2019·International Journal of Clinical Oncology·Keiichi JinguHaruo Matsushita
May 9, 2019·The Journal of Medical Investigation : JMI·Chisato TonoisoAkira Tangoku
Mar 30, 2019·Annals of Gastroenterological Surgery·Tomoki MakinoYuichiro Doki
Mar 6, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Baoqing ChenQiaoqiao Li

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