Abstract
The objectives of this study were to evaluate long-term results of concurrent chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin and the potential benefit of consolidation chemotherapy in patients with anal squamous cell carcinoma (ASCC). Between January 1995 and February 2006, 31 patients with ASCC were treated with CRT. Radiotherapy was administered at 45 Gy over 5 weeks, followed by a boost of 9 Gy to complete or partial responders. Chemotherapy consisted of 5-fluorouracil (750 or 1,000 mg/m2) daily on days 1 to 5 and days 29 to 33; and, cisplatin (75 or 100 mg/m2) on day 2 and day 30. Twelve patients had T3-4 disease, whereas 18 patients presented with lymphadenopathy. Twenty-one (67.7%) received consolidation chemotherapy with the same doses of 5-fluorouracil and cisplatin, repeated every 4 weeks for maximum 4 cycles. Nineteen patients (90.5%) completed all four courses of consolidation chemotherapy. After CRT, 28 patients showed complete responses, while 3 showed partial responses. After a median follow-up period of 72 months, the 5-year overall, disease-free, and colostomy-free survival rates were 84.7%, 82.9% and 96.6%, demonstrating that CRT with 5-fluorouracil and cisplatin yields a good outcome in terms of sur...Continue Reading
References
Feb 1, 1992·Annals of Surgery·R DociG Lamonica
Jun 11, 1992·Diseases of the Colon and Rectum·R S ZelnickT A Fox
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B J CummingsC N Catton
Aug 1, 1989·The American Journal of Medicine·J A AjaniS Wallace
Dec 1, 1989·International Journal of Radiation Oncology, Biology, Physics·L L HughesR G Martin
Jun 7, 1989·Journal of the National Cancer Institute·B SischyH G Seydel
Jul 1, 1987·Diseases of the Colon and Rectum·M S FlamJ Wade
Feb 1, 1985·The American Journal of Medicine·L LeichmanC Leichman
May 1, 1974·Diseases of the Colon and Rectum·N D NigroB Considine
Nov 15, 1984·Cancer·B CummingsW Rider
Jun 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T A RichB Levin
Jul 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J A MartensonA B Benson
Sep 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M FlamK Murray
Dec 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R DociL Lozza
Feb 1, 1997·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·A Liabeuf, J Faivre
May 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H BartelinkM Pierart
Jun 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D PeiffertJ P Gérard
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·A S AllalJ M Kurtz
May 8, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J P GerardF Mornex
Feb 25, 2003·Cancer·Arthur HungNora Janjan
Jun 28, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurie MarkmanUNKNOWN Gynecologic Oncology Group
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chandra P BelaniGlenn M Mills
Dec 4, 2003·British Journal of Cancer·L ChauveincR J Salmon
Nov 15, 2005·Cancer·Hakan BozcukBurhan Savas
Jan 10, 2006·Seminars in Oncology·Bernard J Cummings
May 2, 2007·The Oncologist·Francesco GrossiOrnella Belvedere
May 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neal J MeropolRobert J Mayer
Citations
Dec 5, 2008·World Journal of Surgery·Christian Marin-MullerQizhi Yao
Feb 18, 2011·American Journal of Clinical Oncology·Agustin AvilesM Jesus Nambo
Feb 5, 2011·BMC Cancer·Maria G ZampinoRoberto Orecchia
Oct 31, 2009·Expert Opinion on Therapeutic Targets·Thomas Amann, Claus Hellerbrand
Apr 21, 2009·Expert Review of Anticancer Therapy·Nicolas C BuchsPascal Gervaz
Apr 1, 2011·Cancer Treatment Reviews·Faye Lim, Rob Glynne-Jones
Jan 18, 2011·Journal of Surgical Oncology·L Moureau-ZabottoM Resbeut
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Saeid Abediankenari, Fereshteh Jeivad
Mar 27, 2015·Journal of Gastrointestinal Cancer·Hend Ahmed El-HadaadSameh Roshdy
Feb 19, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Sanja A FarkasTorbjörn K Nilsson
Apr 27, 2013·Radiation Oncology Journal·Kyung Hwan KimWoong Sub Koom
Jan 11, 2019·Contrast Media & Molecular Imaging·Ramin SadeghiGiorgio Treglia