Chemoreduction for retinoblastoma. Analysis of tumor control and risks for recurrence in 457 tumors

American Journal of Ophthalmology
Carol L ShieldsJerry A Shields

Abstract

To evaluate retinoblastoma control following chemoreduction. Interventional case series. Prospective. Single center trial. 457 retinoblastomas in 193 eyes of 125 patients. Nonrandomized, noncomparative study. All patients received intravenous vincristine, etoposide, and carboplatin,. The tumors were managed with chemoreduction alone (group W) or chemoreduction combined with thermotherapy (group X), cryotherapy (group Y), or both thermotherapy and cryotherapy (group Z). Tumor recurrence in each treatment group. Of 457 retinoblastomas, 63 (14%) were in group W, 256 (56%) in group X, 127 (28%) in group Y, and 11 (2%) in group Z. The tumor was located in the macula in 33 (52%) of group W, 109 (43%) of group X, 3 (2%) of group Y, and 9 (1%) of group Z. The mean tumor thickness at initial examination was 7 mm for group W, 4 mm for group X, 2 mm for group Y, and 3 mm for group Z. Using Kaplan-Meier estimates, recurrence of the individual retinoblastoma at 7 years was found in 45% of group W and 18% for combined groups X, Y, and Z. Risk factors predictive of tumor recurrence by multivariate analysis included macular tumor location for all groups and additionally female gender for group W and increasing tumor thickness for groups X, Y, ...Continue Reading

References

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Citations

Feb 4, 2012·Lasers in Medical Science·Samuel K HoustonTimothy G Murray
Feb 22, 2012·Current Oncology Reports·Sidnei Epelman
Nov 17, 2012·Eye·R C Eagle
Dec 8, 2004·Retina·Carol L ShieldsJerry A Shields
Dec 9, 2010·International Ophthalmology Clinics·Samuel K HoustonCristina E Fernandes
Jul 19, 2013·The British Journal of Ophthalmology·Annette KünkeleJohannes H Schulte
Jan 24, 2007·Molecular Cancer Therapeutics·Rong Stephanie HuangM Eileen Dolan
Jul 17, 2012·Journal of Neurosurgery. Pediatrics·Pascal JabbourCarol Shields
Oct 10, 2013·Indian Journal of Ophthalmology·Bhavna ChawlaRajvardhan Azad
Sep 19, 2012·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Rachna MeelSameer Bakhshi
May 6, 2014·The British Journal of Ophthalmology·Jun Ah LeeKyung Duk Park
Jan 2, 2013·International Ophthalmology·Francesco PichiPaolo Nucci
Mar 17, 2012·Indian Journal of Pediatrics·Anish RayTribhawan S Vats
Dec 6, 2011·Ophthalmology·Carlos BianciottoJerry A Shields
Jul 18, 2012·Journal of Pediatric Ophthalmology and Strabismus·Xunda JiPeiquan Zhao
Dec 24, 2010·Journal of Pediatric Ophthalmology and Strabismus·Jaeyoon ChungCarol L Shields
Jun 5, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D MastrangeloT Hadjistilianou
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Sep 15, 2004·American Journal of Ophthalmology·J William Harbour
Sep 17, 2015·American Journal of Ophthalmology·Marcus C de JongTero Kivelä
Apr 18, 2016·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Paola ValenteLuca Buzzonetti
Jul 5, 2012·Pediatric Hematology and Oncology·Ali VaranMünevver Büyükpamukçu
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Mar 13, 2010·Current Opinion in Ophthalmology·Carol L Shields, Jerry A Shields
Aug 18, 2010·Korean Journal of Ophthalmology : KJO·Joo Young ShinHyo Seop Ahn
Dec 18, 2010·Korean Journal of Ophthalmology : KJO·Jae Min KimYoung Suk Yu
Jun 8, 2018·The British Journal of Ophthalmology·David H AbramsonLarissa Habib
Dec 17, 2008·Seminars in Ophthalmology·Carol L Shields

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